22582-52-1

Basic information

• Product Name: 1-(2-methyl-1H-indol-3-yl)ethanone
• Synonyms: 1-(2-methyl-1H-indol-3-yl)ethanone
• CAS NO: 22582-52-1
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.21114
• Mol File: 22582-52-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 197 °C
• Boiling Point: 340.4°Cat760mmHg
• Flash Point: 167.6°C
• Appearance: /
• Density: 1.157g/cm³
• Vapor Pressure: 8.64E-05mmHg at 25°C
• Refractive Index: 1.631
• PKA: 15.95±0.30(Predicted)
• CAS DataBase Reference: 1-(2-methyl-1H-indol-3-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-methyl-1H-indol-3-yl)ethanone(22582-52-1)
• EPA Substance Registry System: 1-(2-methyl-1H-indol-3-yl)ethanone(22582-52-1)

Safety Data

• Hazardous Substances Data: 22582-52-1(Hazardous Substances Data)

Usage

General Description

1-(2-methyl-1H-indol-3-yl)ethanone, also known as 2-Methyl-1-(3-indolyl)ethanone, is a chemical compound with the molecular formula C11H11NO. It is a ketone derivative and contains an indole ring, which is a heterocyclic aromatic ring structure. 1-(2-methyl-1H-indol-3-yl)ethanone is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It may also have potential applications in the field of medicinal chemistry for its pharmacological properties. Its structural features make it a versatile building block for the synthesis of diverse molecules for various applications.

InChI:InChI=1/C11H11NO/c1-7-11(8(2)13)9-5-3-4-6-10(9)12-7/h3-6,12H,1-2H3

Upstream product

• 5538-51-2 O-acetylsalicyloyl chloride 
• 95-20-5 2-methyl-1H-indole 
• 104-93-8 p-methylanizole 
• 37842-85-6 1-acetyl-2-methylindole 
• 615-43-0 2-iodophenylamine 
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• 79-04-9 chloroacetyl chloride 

Downstream Products

• 91-55-4 2,3-dimethylindole 
• 95-20-5 2-methyl-1H-indole 
• 103858-98-6 2-(3,5-dimethyl-1⁽²⁾H-pyrazol-4-yl)-aniline 
• 113424-27-4 1-[1-(4-Methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-ethanone 
• 102314-22-7 bis-[1-(2-methyl-indol-3-yl)-ethylidene]-hydrazine 
• 143774-55-4 1-(2-(bromomethyl)-1-(phenylsulfonyl)-1H-indol-3-yl)ethanone 
• 1445973-83-0 C₃₅H₂₈NO₃PS 
• 1445973-96-5 (E)-1-(2-(4,5-dichloro-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl)-3-(dimethylamino)prop-2-en-1-one 
• 1445973-84-1 (E)-1-(2-(2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl)ethanone 
• 1445973-85-2 (E)-1-(2-(4, 5-dimethoxy-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl)ethanone 
• 1445973-86-3 (E)-1-(2-(2-(6-nitrobenzo[d][1,3]dioxol-5-yl)vinyl)-1-(phenylsulfonyl)-1H-indol-3-yl)ethanone 
• 1445973-87-4 (E)-1-(2-(4-chloro-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl)ethanone 
• 1445973-88-5 (E)-1-(2-(4-fluoro-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl)ethanone 

Relevant articles and documents

Intermolecular dearomative C2-arylation of N-Ac indoles activated by FeCl3

We report the FeCl3-mediated direct addition of electron-rich arenes to the C2-position of electrophilic N-Ac indoles under mild conditions (room temperature, air). No functional group is required on the arene nucleophile: one of its C-H bonds is added to the C2=C3 double bond of the indole nucleus in a Friedel-Crafts-type reaction. This dearomatisation process delivered a broad range of C2-arylated indolines.