22583-90-0

Basic information

• Product Name: 1,2,3,4-Tetrahydro-N-methyl-2-naphthalenamine hydrochloride
• Synonyms: 1,2,3,4-Tetrahydro-N-methyl-2-naphthalenamine hydrochloride;1,2,3,4-Tetrahydro-N-methyl-2-phthalemine hydrochloride;N-METHYL-1,2,3,4-TETRAHYDRONAPHTHALEN-2-AMINE HYDROCHLORIDE
• CAS NO: 22583-90-0
• Molecular Formula: C₁₁H₁₅N*ClH
• Molecular Weight: 197.7
• Mol File: 22583-90-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 212 °C
• Boiling Point: 296.7oC at 760 mmHg
• Flash Point: 133.3oC
• Appearance: /
• Vapor Pressure: 0.00106mmHg at 25°C
• CAS DataBase Reference: 1,2,3,4-Tetrahydro-N-methyl-2-naphthalenamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-Tetrahydro-N-methyl-2-naphthalenamine hydrochloride(22583-90-0)
• EPA Substance Registry System: 1,2,3,4-Tetrahydro-N-methyl-2-naphthalenamine hydrochloride(22583-90-0)

Safety Data

• Hazardous Substances Data: 22583-90-0(Hazardous Substances Data)

Usage

General Description

1,2,3,4-Tetrahydro-N-methyl-2-naphthalenamine hydrochloride is a chemical compound with the chemical formula C12H17N · HCl. It is a hydrochloride salt form of a naphthalenamine derivative, which is used as an intermediate in the synthesis of pharmaceutical and organic compounds. 1,2,3,4-Tetrahydro-N-methyl-2-naphthalenamine hydrochloride is typically used in the production of certain medications and drugs, and it may also have potential applications in chemical research and development. Additionally, it is important to handle and store this chemical carefully, as it may pose health and safety risks if not used properly.

InChI:InChI=1/C11H15N.ClH/c1-12-11-7-6-9-4-2-3-5-10(9)8-11;/h2-5,11-12H,6-8H2,1H3;1H

Upstream product

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• 2954-50-9 2-aminotetralin 
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• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 

Relevant articles and documents

Discovery and structural analyses of S-adenosyl-l-homocysteine hydrolase inhibitors based on non-adenosine analogs

Optimization of a new series of S-adenosyl-l-homocysteine hydrolase (AdoHcyase) inhibitors based on non-adenosine analogs led to very potent compounds 14n, 18a, and 18b with IC50 values of 13 ± 3, 5.0 ± 2.0, and 8.5 ± 3.1 nM, respectively. An X-ray crystal structure of AdoHcyase with NAD+ and 18a showed a novel open form co-crystal structure. 18a in the co-crystals formed intramolecular eight membered ring hydrogen bond formations. A single crystal X-ray structure of 14n also showed an intramolecular eight-membered ring hydrogen bond interaction.

Probing the proposed phenyl-A region of the sigma-1 receptor.

The proposed phenyl-A region of sigma (sigma) receptors accommodates several structural features. In this study we explored the possibility that appropriate structural features located at the phenyl-A region of sigma receptor sites could lead to more potent and selective agents for the sigma receptor subtypes. By keeping the phenyl-B substituent as the optimum omega-phenylpentyl moiety, and varying substituents in the phenyl-A region, we have observed changes in binding potency and selectivity at the sigma receptor subtypes. SAR for the binding of these compounds at sigma-2 sites was also examined.

Bicyclo-substituted phenylacetonitrile derivatives

The invention relates to compounds of the formula: STR1 which are useful cardiovascular agents.