226085-15-0 Usage
Molecular Structure
1H-Pyrrolo[2,3-b]pyridine core with a bromine atom attached at position 3, and a 1-tert-butyldimethylsilyl group.
Usage
Building block in organic synthesis and medicinal chemistry for the preparation of biologically active molecules and pharmaceuticals.
Protective Group
Tert-butyldimethylsilyl group provides protection for reactive functional groups during synthetic reactions.
Versatility
A valuable reagent in chemical research and drug discovery due to its protective properties.
Functionalization Site
Bromine atom allows for further functionalization, enabling modification and diversification of the compound's chemical properties.
Check Digit Verification of cas no
The CAS Registry Mumber 226085-15-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,6,0,8 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 226085-15:
(8*2)+(7*2)+(6*6)+(5*0)+(4*8)+(3*5)+(2*1)+(1*5)=120
120 % 10 = 0
So 226085-15-0 is a valid CAS Registry Number.
InChI:InChI=1/C13H19BrN2Si/c1-13(2,3)17(4,5)16-9-11(14)10-7-6-8-15-12(10)16/h6-9H,1-5H3
226085-15-0Relevant academic research and scientific papers
Alvarez, Mercedes,Fernández, David,Joule, John A.
, p. 615 - 620 (1999)
The synthesis of 1-protected 3-trimethylstannyl-7-azaindoles and their coupling with aryl and heteroaryl halides is described.
Barl, Nadja M.,Malakhov, Vladimir,Mathes, Christian,Lustenberger, Philipp,Knochel, Paul
, p. 692 - 700 (2015)
The preparation of various 2-(7-azaindolyl)carboxylic esters by Pd-catalyzed coupling of Reformatsky reagents with TBDMS-protected 3-bromo-7-azaindoles leading to a wide range of arylated ester derivatives is reported. After removal of the protecting group, the corresponding free 2-(7-azaindolyl)carboxylic esters are obtained in satisfactory yields.
PYRIDINONYL PDK1 INHIBITORS
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Page/Page column 72, (2008/06/13)
The present invention provides pyridinonyl PDKl inhibitors and methods of treating cancer using the same.
