22614-72-8

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1322, 1946 DOI: 10.1021/ja01211a066

InChI:InChI=1/C9H6ClNO/c10-7-3-1-6-2-4-9(12)11-8(6)5-7/h1-5H,(H,11,12)

Upstream product

• 156820-88-1 4,7-dichloro-quinolin-2-ol 
• 150869-41-3 methyl (E)-3-(4-chloro-2-nitrophenyl)acrylate 
• 150869-43-5 (E)-3-[4-Chloro-2-(2-nitro-acetylamino)-phenyl]-acrylic acid methyl ester 
• 150869-42-4 methyl trans-4-chloro-2-aminocinnamate 
• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 445041-60-1 (E)-N-(3-chlorophenyl)-3-ethoxypropenamide 

Downstream Products

• 613-77-4 2,7-dichloroquinoline 
• 1219130-54-7 7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-quinolin-2-one 
• 5443-04-9 N⁴,N⁴-diethyl-N¹-(7-chloro-[2]quinolyl)-1-methyl-butanediyldiamine 
• 143816-81-3 methyl D,L-2-<3-<(7-chloroquinolinyl)thio>phenoxy>propanoate 
• 143816-63-1 2-[3-(7-Chloro-quinolin-2-ylsulfanyl)-phenoxy]-propionic acid 
• 143816-79-9 7-chloro-2-<(3-methoxyphenyl)thio>quinoline 
• 143816-80-2 7-chloro-2-<(3-hydroxyphenyl)thio>quinoline 

Relevant academic research and scientific papers

3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF M4 MUSCARINIC ACETYLCHOLINE RECEPTOR

Provided are cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor, compositions comprising said compounds, and uses of said compounds in the treatment or prevention of diseases in which M4 muscarinic acetylcholine receptors are involved, especially neurological and psychiatric disorders and diseases.

2-(4-Alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists

With the aim of identifying structurally novel, centrally acting histamine H3 antagonists, a series of 2-(4-alkylpiperazin-1-yl)quinolines was prepared. Systematic variation of the substituents led to highly potent histamine H3 antagonists with low polar surface area and appropriate log P for blood-brain barrier penetration.