226215-74-3

Upstream product

• 131543-46-9 Glyoxal 
• 210993-14-9 (1R,2S)-2-({2-[(1S,2R)-2-hydroxy-1-methyl-2-phenylethylamino]ethyl}amino)-1-phenylpropan-1-ol 
• 151528-61-9 (1S,2R)-N,N'-bis-<(2-hydroxy-1-methyl-2-phenyl)ethyl>oxamide 
• 492-41-1 (1R,2S)-norephedrine 

Downstream Products

• 136021-21-1 1,4-bis<(1'S,2'R)-(2'-hydroxy-1'-methyl-2'-phenyl)>ethylpiperazine 

Relevant academic research and scientific papers

A new method for the preparation of unsymmetrical 1,4-substituted piperazine derivatives

Symmetrical and unsymmetrical N,N'-piperazine derivatives of (-)- norephedrine and o-aminophenol were synthesized stereoselectively in yields >70% by reduction of the corresponding N,N'-ethylenebisoxazolidine heterocycles. The stereochemistry at the ring fusion carbons was established by NMR spectroscopy and X-ray crystallography.