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226249-16-7

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226249-16-7 Usage

General Description

"(R)-N-(2-oxo-2-(pyrrolidin-3-ylamino)ethyl)-3-(trifluoromethyl)benzamide" is a chemical compound with a complex molecular structure. Its molecular formula is C16H18F3N3O2. (R)-N-(2-oxo-2-(pyrrolidin-3-ylaMino)-ethyl)-3-(trifluoroMethyl)benzaMide is a benzamide derivative that contains a trifluoromethyl group and a pyrrolidin-3-ylamino group. It is commonly used as a research chemical and is known to have potential pharmaceutical properties. The presence of the trifluoromethyl group and the pyrrolidin-3-ylamino group in its structure suggests that it may have biological activity and could potentially be used in the development of new drugs. Further research is needed to fully understand its potential applications and effects.

Check Digit Verification of cas no

The CAS Registry Mumber 226249-16-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,6,2,4 and 9 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 226249-16:
(8*2)+(7*2)+(6*6)+(5*2)+(4*4)+(3*9)+(2*1)+(1*6)=127
127 % 10 = 7
So 226249-16-7 is a valid CAS Registry Number.

226249-16-7Relevant articles and documents

PIPERAZINYL 3-AMINOPYRROLIDINE DERIVATIVES AS A CCR2 ANTAGONIST

-

, (2012/07/31)

The present invention relates to compounds of chemical formula 1 and having CCR2 (chemokine receptor 2) antagonistic effects, and salts or isomers thereof. These compounds are very useful for treating, preventing, or relieving rheumatoid arthritis, arteri

Discovery of INCB3284, a potent, selective, and orally bioavailable hCCR2 antagonist

Xue, Chu-Biao,Feng, Hao,Cao, Ganfeng,Huang, Taisheng,Glenn, Joseph,Anand, Rajan,Meloni, David,Zhang, Ke,Kong, Lingquan,Wang, Anlai,Zhang, Yingxin,Zheng, Changsheng,Xia, Michael,Chen, Lihua,Tanaka, Hiroyuki,Han, Qi,Robinson,Modi, Dilip,Storace, Lou,Shao, Lixin,Sharief, Vaqar,Li, Mei,Galya, Laurine G.,Covington, Maryanne,Scherle, Peggy,Diamond, Sharon,Emm, Tom,Yeleswaram, Swamy,Contel, Nancy,Vaddi, Kris,Newton, Robert,Hollis, Greg,Friedman, Steven,Metcalf, Brian

, p. 450 - 454 (2011/08/22)

We report the identification of 13 (INCB3284) as a potent human CCR2 (hCCR2) antagonist. INCB3284 exhibited an IC50 of 3.7 nM in antagonism of monocyte chemoattractant protein-1 binding to hCCR2, an IC 50 of 4.7 nM in antagonism of c

Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series

Moree, Wilna J.,Kataoka, Ken-ichiro,Ramirez-Weinhouse, Michele M.,Shiota, Tatsuki,Imai, Minoru,Tsutsumi, Takaharu,Sudo, Masaki,Endo, Noriaki,Muroga, Yumiko,Hada, Takahiko,Fanning, Dewey,Saunders, John,Kato, Yoshinori,Myers, Peter L.,Tarby, Christine M.

, p. 1869 - 1873 (2008/09/19)

SAR studies were conducted around lead compound 1 using high-throughput parallel solution and solid phase synthesis. Our lead optimization efforts led to the identification of several CCR2b antagonists with potent activity in both binding and functional a

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