22632-36-6

Basic information

• Product Name: Pentanoic acid, 2-propyl-, hydrazide
• Synonyms: Pentanoic acid, 2-propyl-, hydrazide
• CAS NO: 22632-36-6
• Molecular Formula: C₈H₁₈N₂O
• Molecular Weight: 0
• Mol File: 22632-36-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 294.5°C at 760 mmHg
• Flash Point: 131.9°C
• Appearance: /
• Density: 0.927g/cm³
• Vapor Pressure: 0.00162mmHg at 25°C
• Refractive Index: 1.454
• CAS DataBase Reference: Pentanoic acid, 2-propyl-, hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanoic acid, 2-propyl-, hydrazide(22632-36-6)
• EPA Substance Registry System: Pentanoic acid, 2-propyl-, hydrazide(22632-36-6)

Safety Data

• Hazardous Substances Data: 22632-36-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H18N2O/c1-3-5-7(6-4-2)8(11)10-9/h7H,3-6,9H2,1-2H3,(H,10,11)

Upstream product

• 99-66-1 valproic acid 
• 2936-08-5 valproyl chloride 
• 22632-59-3 methyl 2-propylvalerate 

Downstream Products

• 38068-38-1 N'-Cyclohexyldipropylacetohydrazid 
• 340294-74-8 N'-(4-chlorobenzylidene)-2-propylpentanehydrazide 
• 38068-35-8 N'-Isopropylidendipropylacetohydrazid 
• 38068-37-0 N'-Cyclohexylidendipropylacetohydrazid 
• 38078-04-5 N'-Benzyldipropylacetohydrazid 

Relevant articles and documents

Synthesis, Characterization, And antI-Cancer Activity of some new n′ (2-Oxoindolin-3-Ylidene)-2-Propylpentane Hydrazide-Hydrazones derivatives

Eight novel N′-(2-oxoindolin-3-ylidene)-2-propylpentane hydrazide-hydrazone derivatives 4a-h were synthesized and fully characterized by IR, NMR ( (1H-NMR and 13C-NMR), elemental analysis, and X-ray crystallography. The cyto-toxicity and in vitro anti-cancer evaluation of the prepared compounds have been assessed against two different human tumour cell lines including human liver (HepG2) and leukaemia (Jurkat), as well as in normal cell lines derived from human embryonic kidney (HEK293) using MTT assay. The compounds 3e, 3f, 4a, 4c, and 4e revealed promising anti-cancer activities in tested human tumour cells lines (IC50 values between 3 and 7 μM) as compared to the known anti-cancer drug 5-Fluorouracil (IC50 32-50 μM). Among the tested compounds, 4a showed specificity against leukaemia (Jurkat) cells, with an IC50 value of 3.14 μM, but this compound was inactive in liver cancer and normal cell lines.

Synthesis and biological activity of Schiff base series of valproyl, N-valproyl glycinyl, and N-valproyl-4-aminobenzoyl hydrazide derivatives

Series of Schiff bases of valproic acid hydrazide, N-valproylglycine hydrazide and N-valproyl-4-aminobenzoyl hydrazide derivatives were synthesized and characterized by IR, NMR (1H- and 13C-NMR) and elemental analysis. The prepared compounds were evaluated in transgenic zebrafish embryos (Tg: flil-1: enhanced green fluorescent protein (EGFP)) for antiangiogenic activity and in HepG2 liver carcinoma cell line for anti cancer activity. The Schiff bases of N-valproylglycine hydrazide derivatives were most potent in term of suppressing angiogenic blood vessels formation and anticancer activity at very low concentration, followed by the Schiff bases of valproic acid hydrazide derivatives which exhibited moderate activity, while the Schiff bases of N-valproyl-4-aminobenzoyl hydrazide derivatives, ethyl 4-(2-propylpentanamido)benzoate (VABE) and N-(4-(hydrazinecarbonyl)phenyl)-2- propylpentanamide (VABH) in contrast exhibited pro-angiogenic activity and weaker anticancer activity which mean that these derivatives targeted a common signaling pathway in term of affecting the blood vessels formation.