22636-41-5

Upstream product

• 79233-46-8 [(2S,3R,12bS)-3-((R)-1-Methoxy-ethyl)-4-oxo-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizin-2-yl]-acetonitrile 
• 79233-46-8 [(2S,3S,12bS)-3-((R)-1-Methoxy-ethyl)-4-oxo-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizin-2-yl]-acetonitrile 
• 79228-03-8 (2R,3R,12bS)-2-Hydroxymethyl-3-((R)-1-methoxy-ethyl)-2,3,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizin-4-one 
• 79228-03-8 (2R,3S,12bS)-2-Hydroxymethyl-3-((R)-1-methoxy-ethyl)-2,3,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizin-4-one 
• 79227-99-9 2-[2-((2R,3R)-2-Bromo-3-methoxy-butyryl)-2,3,4,9-tetrahydro-1H-β-carbolin-1-ylmethyl]-malonic acid diethyl ester 
• 79228-01-6 (3R,12bR)-3-((S)-1-Methoxy-ethyl)-4-oxo-3,4,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizine-2,2-dicarboxylic acid diethyl ester 
• 79233-45-7 Methanesulfonic acid (2R,3R,12bS)-3-((R)-1-methoxy-ethyl)-4-oxo-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizin-2-ylmethyl ester 
• 79228-06-1 (2S,12bS)-2-(4,4-Dimethyl-4,5-dihydro-oxazol-2-ylmethyl)-3-eth-(E)-ylidene-2,3,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizin-4-one 
• 79228-02-7 (2R,12bS)-3-((R)-1-Methoxy-ethyl)-4-oxo-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizine-2-carboxylic acid ethyl ester 
• 79227-96-6 2-{[2-(1H-Indol-3-yl)-ethylcarbamoyl]-methyl}-malonic acid diethyl ester 
• 79235-44-2 (2S,12bS)-2-(4,4-Dimethyl-4,5-dihydro-oxazol-2-ylmethyl)-3-eth-(E)-ylidene-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizine 
• 79235-42-0 2-(2,3,4,9-Tetrahydro-1H-β-carbolin-1-ylmethyl)-malonic acid diethyl ester 
• 67045-81-2 [(2S,12bS)-3-Eth-(E)-ylidene-4-oxo-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizin-2-yl]-acetonitrile 
• 80249-82-7 C₁₈H₂₀N₂O₂ 

Relevant academic research and scientific papers

A radical cyclization strategy for the concise total synthesis of (±)-geissoschizine

A short synthetic route to (±)-geissoschizine (1) was developed that features the construction of a Corynanthe-skeleton via radical cyclization of vinyl iodide, which was easily prepared by assembly of three fragments. New pentacyclic molecules formed by the radical cyclization were also reported.

A NEW SYNTHESIS OF INDOLOQUINOLIZIDINE DERIVATIVES: A FORMAL TOTAL SYNTHESIS OF (+-)-GEISSOSCHIZINE

A stereospecific elimination process has been developed for introducing the E-ethylidene group in a transformation of tryptamine into methyl (+-)-geissoschizoate.