22636-68-6Relevant academic research and scientific papers
FUNCTIONAL SKIN COATING POLYMER
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Page/Page column 4, (2021/12/08)
Film-forming polymers that contain covalently-attached or non-covalently bound light-filtering, e.g., UV-absorbing, compounds and their use as a skin-protectant coating, such as a sunscreen, are disclosed.
Atmospheric Oxygen Mediated Radical Hydrothiolation of Alkenes
McCourt, Ruairí O.,Scanlan, Eoin M.
supporting information, p. 15804 - 15810 (2020/10/26)
A mild, metal-free, atmospheric oxygen-mediated radical hydrothiolation of alkenes (and alkyne) is reported. A variety of sulfur containing motifs including alkanethiols, thiophenols and thioacids undergo an atmospheric oxygen-mediated radical hydrothiolation reaction with a plethora of alkenes in good yield with excellent functional group compatibility, typically with short reaction times to furnish a range of functionalized products. Biomolecules proved tolerant to the conditions and the procedure is robust and easily executable requiring no specialized equipment. Concise mechanistic studies confirm the process proceeds through radical intermediates in a thiol-ene reaction manifold. The methodology offers an efficient “green” approach for thiol-ene mediated “click” ligation and a milder alternative to thermally initiated hydrothiolation processes.
Enantioselective Three-Component Fluoroalkylarylation of Unactivated Olefins through Nickel-Catalyzed Cross-Electrophile Coupling
Tu, Hai-Yong,Wang, Fang,Huo, Liping,Li, Yuanbo,Zhu, Shengqing,Zhao, Xian,Li, Huan,Qing, Feng-Ling,Chu, Lingling
supporting information, p. 9604 - 9611 (2020/07/14)
A nickel-catalyzed, enantioselective, three-component fluoroalkylarylation of unactivated alkenes with aryl halides and perfluoroalkyl iodides has been described. This cross-electrophile coupling protocol utilizes a chiral nickel/BiOx system as well as a pendant chelating group to facilitate the challenging three-component, asymmetric difunctionalization of unactivated alkenes, providing direct access to valuable chiral β-fluoroalkyl arylalkanes with high efficiency and excellent enantioselectivity. The mild conditions allow for a broad substrate scope as well as good functional group toleration.
Mechanistic studies on the nickel-catalyzed polymerization of isocyanides
Deming, Timothy J.,Novak, Bruce M.
, p. 9101 - 9111 (2007/10/02)
All mechanistic aspects of nickel-mediated isocyanide polymerizations have been examined experimentally. Chain initiation has been studied by 13C{1H} NMR at low temperature using a living polymerization system. Chain propagation has been examined by cyclic voltammetry, ESR spectroscopy, magnetic susceptibility measurements, temperature dependent kinetic studies, and substituent effect analysis. The chain-propagation studies were performed on both living and classical heterogeneous systems and were found to be invariant with respect to the type of nickel initiator used. Finally, chain-transfer reactions were studied by NMR, kinetic studies, substituent effect analyses, and chemical studies. Comprehensive mechanistic schemes have been derived from the experimental data and are presented as the most probable reaction pathways.
