226398-39-6 Usage
Chemical structure
A complex chemical compound containing piperidine, carboxylic acid, sulfonyl, and ester functional groups.
Building block
Commonly used in organic synthesis and pharmaceutical research.
Potential applications
Can be used as a drug intermediate or in the development of new drugs due to its diverse chemical structure.
Field of application
Has potential applications in materials science and chemical engineering.
Functional groups
Contains a combination of functional groups that may contribute to its reactivity and potential uses.
Ester functional group
The presence of the ester functional group may contribute to its reactivity and potential uses in various fields.
Sulfonyl functional group
The presence of the sulfonyl functional group may contribute to its reactivity and potential uses in various fields.
1,1-Dimethylethyl
A type of alkyl group that is part of the chemical structure of the compound.
4-Methyl
A type of alkyl group that is part of the chemical structure of the compound.
4-(4-chlorophenoxy)phenyl
A type of aryl group that is part of the chemical structure of the compound.
Check Digit Verification of cas no
The CAS Registry Mumber 226398-39-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,6,3,9 and 8 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 226398-39:
(8*2)+(7*2)+(6*6)+(5*3)+(4*9)+(3*8)+(2*3)+(1*9)=156
156 % 10 = 6
So 226398-39-6 is a valid CAS Registry Number.
226398-39-6Relevant articles and documents
Synthesis and structure - Activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis
Aranapakam, Venkatesan,Davis, Jamie M.,Grosu, George T.,Baker, Jannie,Ellingboe, John,Zask, Arie,Levin, Jeremy I.,Sandanayaka, Vincent P.,Du, Mila,Skotnicki, Jerauld S.,DiJoseph, John F.,Sung, Amy,Sharr, Michele A.,Killar, Loran M.,Walter, Thomas,Jin, Guixian,Cowling, Rebecca,Tillett, Jeff,Zhao, Weiguang,McDevitt, Joseph,Xu, Zhang Bao
, p. 2376 - 2396 (2007/10/03)
The matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases that play a key role in both physiological and pathological tissue degradation. In our preceding paper, we have reported on a series of novel and orally active N-hydroxy-α-phenylsulfonylacetamide derivatives. However, these compounds had two drawbacks (moderate selectivity and chirality issues). To circumvent these two problems, a series of novel and orally active N-substituted 4-benzenesulfonylpiperidine-4-carboxylic acid hydroxyamide derivatives have been synthesized. The present paper deals with the synthesis and SAR of these compounds. Among the several compounds synthesized, derivative 55 turned out to be a potent, selective, and an orally active MMP inhibitor in the clinically relevant advanced rabbit osteoarthritis model. Detailed pharmacokinetics and metabolism data are described.
