226398-50-1 Usage
General Description
4-(4-fluoro-benzenesulfonyl)-piperidine-1-carboxylic acid tert-butyl ester, also known as Boc-4-(4-fluorophenylsulfonyl)piperidin-1-ylcarboxylate, is a chemical compound commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds. It is an ester derivative of piperidine-1-carboxylic acid, featuring a tert-butyl group and a 4-fluorobenzenesulfonyl moiety. 4-(4-FLUORO-BENZENESULFONYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is frequently employed in drug discovery and medicinal chemistry research as a precursor, intermediate, or reagent, and it is valued for its versatility and compatibility with a wide range of synthetic strategies. Additionally, it has shown potential as an agent for the treatment of various medical conditions, including cancer, neurological disorders, and infectious diseases, making it an important compound in the development of new therapeutic interventions.
Check Digit Verification of cas no
The CAS Registry Mumber 226398-50-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,6,3,9 and 8 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 226398-50:
(8*2)+(7*2)+(6*6)+(5*3)+(4*9)+(3*8)+(2*5)+(1*0)=151
151 % 10 = 1
So 226398-50-1 is a valid CAS Registry Number.
226398-50-1Relevant articles and documents
TETRAHYDROPYRIDOPYRAZINES MODULATORS OF GPR6
-
Paragraph 0161, (2015/07/02)
The present invention provides compounds of formula I: which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.
PYRAZINES MODULATORS OF GPR6
-
Paragraph 0142, (2015/09/22)
The present invention provides compounds of formula (I): which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.
Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent anti-HIV-1 activity
Imamura, Shinichi,Ichikawa, Takashi,Nishikawa, Youichi,Kanzaki, Naoyuki,Takashima, Katsunori,Niwa, Shinichi,Iizawa, Yuji,Baba, Masanori,Sugihara, Yoshihiro
, p. 2784 - 2793 (2007/10/03)
We incorporated various polar groups into previously described piperidine-4-carboxamide CCR5 antagonists to improve their metabolic stability in human hepatic microsomes. Introducing a carbamoyl group into the phenyl ring of the 4-benzylpiperidine moiety
