226398-62-5

Basic information

• Product Name: 4-(4-BROMO-BENZENESULFONYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 4-(4-BROMO-BENZENESULFONYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-butyl 4-(4-bromophenylsulfonyl)piperidine-1-carboxylate;tert-Butyl 4-(4-bromo-benzenesulfonyl)piperidine-1-carboxylate;1-Boc-4-(4-BroMobenzenesulfonyl)piperidine;1-Piperidinecarboxylic acid, 4-[(4-broMophenyl)sulfonyl]-, 1,1-diMethylethyl ester;1-Boc-4-(4-Bromobenzenesulfonyl)
• CAS NO: 226398-62-5
• Molecular Formula: C₁₆H₂₂BrNO₄S
• Molecular Weight: 404.32
• Mol File: 226398-62-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 510.504°C at 760 mmHg
• Flash Point: 262.543°C
• Appearance: /
• Density: 1.403
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(4-BROMO-BENZENESULFONYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-BROMO-BENZENESULFONYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(226398-62-5)
• EPA Substance Registry System: 4-(4-BROMO-BENZENESULFONYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(226398-62-5)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 226398-62-5(Hazardous Substances Data)

Usage

General Description

4-(4-Bromo-benzenesulfonyl)-piperidine-1-carboxylic acid tert-butyl ester is a chemical compound with the molecular formula C18H24BrNO4S. It is a piperidine derivative with a tert-butyl ester group attached to the carboxylic acid functional group. The compound also contains a bromo-benzenesulfonyl group, which is a strong electron-withdrawing group. This chemical is commonly used in organic synthesis and medicinal chemistry as a building block for the synthesis of various organic compounds. It is important to handle this chemical with proper care and in accordance with safety regulations due to its potentially hazardous nature.

InChI:InChI=1/C16H22BrNO4S/c1-16(2,3)22-15(19)18-10-8-14(9-11-18)23(20,21)13-6-4-12(17)5-7-13/h4-7,14H,8-11H2,1-3H3

Upstream product

• 911410-37-2 1-(4-hydroxypiperidin-1-yl)-2,2-dimethylpropan-1-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 226400-32-4 4-(4-bromobenzenesulfonyl)piperidine hydrochloride 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 
• 106-53-6 para-bromobenzenethiol 
• 188527-03-9 4-(4-bromophenylsulfanyl)piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1350351-53-9 tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]sulfonylpiperidine-1-carboxylate 
• 1350351-54-0 tert-butyl 4-[4-[5-amino-6-[2-(3-hydroxyphenyl)ethynyl]pyrazin-2-yl]phenyl]sulfonylpiperidine-1-carboxylate 
• 1450723-99-5 C₁₂H₁₄N₂O₂S 
• 1450724-00-1 4-(1-acetylpiperidine-4-sulfonyl)benzonitrile 
• 1450724-01-2 C₁₅H₁₈N₂O₃S 
• 1450724-04-5 C₁₅H₁₈N₂O₃S 
• 1450724-05-6 4-[1-(tetrahydropyran-4-yl)piperidine-4-sulfonyl]benzonitrile 
• 1450724-02-3 C₁₃H₁₆N₂O₂S 
• 1450724-03-4 C₁₅H₂₀N₂O₂S 
• 1450723-87-1 C₁₃H₂₀N₂O₂S 
• 1450723-88-2 C₁₅H₂₄N₂O₂S 
• 1450723-34-8 N-[[4-(4,4-difluorocyclohexyl)sulfonylphenyl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide 
• 1450724-22-7 C₂₀H₂₃N₃O₆S 
• 1450724-23-8 C₂₂H₂₇N₃O₆S 

Relevant articles and documents

Synthesis and Characterization of N-(4-(Piperidin-4-ylsulfonyl) phenyl)5-vinylpyrimidin-2-amine

Target product N-(4-(piperidin-4-ylsulfonyl)phenyl)5-vinylpyrimidin-2- amine (13) was synthesized using 6-oxopyran-3-carbaldehyde (M1) and 4-hydroxypiperidine (M2) as starting materials by a series of nucleophilic substitution and oxidation. Different aci

UREA/CARBAMATES FAAH MAGL OR DUAL FAAH/MAGL INHIBITORS AND USES THEREOF

Disclosed are compounds that may be used to inhibit the action of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) or dual FAAH/MAGL.

Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors containing 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas were identified using structure-based design techniques. The new compounds displayed improved aqueous solubilities, determined using a high-throughput solubility assessment, relative to previously disclosed urea and amide-containing NAMPT inhibitors. An optimized 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived compound exhibited potent anti-NAMPT activity (18; BC NAMPT IC50 = 11 nM; PC-3 antiproliferative IC50 = 36 nM), satisfactory mouse PK properties, and was efficacious in a PC-3 mouse xenograft model. The crystal structure of another optimized compound (29; NAMPT IC50 = 10 nM; A2780 antiproliferative IC50 = 7 nM) in complex with the NAMPT protein was also determined.