226415-12-9Relevant articles and documents
Synthesis and anti-HIV activity of L-2'-fluoro-2',3'-unsaturated purine nucleosides
Choi, Yongseok,Lee, Kyeong,Hong, Joon H.,Schinazi, Raymond F.,Chu, Chung K.
, p. 4437 - 4440 (1998)
The synthesis of 9-(2,3-dideoxy-2-fluoro-L-glycero-pent-2-eno- furanosyl)adenine and-hypoxanthine has been accomplished by direct condensation of silylated 6-chloropurine with key intermediates 8, which were prepared starting from 2,3-0-isopropylidene-L-glyceraldehyde. The synthesized nucleosides were evaluated against HIV-1 in vitro in primary human lymphocytes (PMB cells). It was found that β-L-Fd4A 12 exhibited moderately potent anti-HIV activity (EC50 1.5 μM).
Structure-activity relationships of 2′-fluoro-2′,3′-unsaturated d-nucleosides as anti-hiv-1 agents
Lee, Kyeong,Choi, Yongseok,Gumina, Giuseppe,Zhou, Wen,Schinazi, Raymond F.,Chu, Chung K.
, p. 1313 - 1320 (2007/10/03)
We studied the structure-activity relationships of a series of 2′-fluoro-2′,3′-unsaturated D-nucleosides against HIV-1 in human peripheral blood mononuclear (PBM) cells. The target compounds 10-21 and 28-33 were prepared by N-glycosylation of the acetate
Synthesis and biological evaluation of a series of 2'-fluorinated- 2',3'-dideoxy-2',3'-didehydro-(L)-nucleosides
Chen, Shu-Hui,Wang, Qin,Mao, John,King, Ivan,Dutschman, Ginger E.,Gullen, Elizabeth A.,Cheng, Yung-Chi,Doyle, Terrence W.
, p. 1589 - 1594 (2007/10/03)
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