226419-21-2

Basic information

• Product Name: 4-Chloro-3,5-dimethoxyaniline
• Synonyms: 4-Chloro-3,5-dimethoxyaniline
• CAS NO: 226419-21-2
• Molecular Formula: C₈H₁₀ClNO₂
• Molecular Weight: 187.6235
• Mol File: 226419-21-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 324.6±37.0 °C(Predicted)
• Appearance: /
• Density: 1.237±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.11±0.10(Predicted)
• CAS DataBase Reference: 4-Chloro-3,5-dimethoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-3,5-dimethoxyaniline(226419-21-2)
• EPA Substance Registry System: 4-Chloro-3,5-dimethoxyaniline(226419-21-2)

Safety Data

• Hazardous Substances Data: 226419-21-2(Hazardous Substances Data)

Upstream product

• 10272-07-8 3.5-dimethoxyaniline 

Downstream Products

• 1272528-60-5 2-chloro-5-iodo-1,3-dimethoxybenzene 
• 1272528-62-7 2-chloro-5-iodobenzene-1,3-diol 
• 1272528-64-9 2-chloro-5-iodo-1,3-phenylene diacetate 
• 1272528-66-1 2-chloro-3-hydroxy-5-iodophenyl acetate 
• 1272528-67-2 2-chloro-3-ethoxy-5-iodophenol 
• 56518-51-5 ethyl 4-chloro-3,5-dimethoxybenzoate 
• 102338-87-4 4-chloro-3,5-dihydroxybenzoic acid 
• 1272528-73-0 2-chloro-5-iodo-3-methoxyphenol 

Relevant articles and documents

Btk INHIBITORS WITH IMPROVED DUAL SELECTIVITY

Disclosed herein is a tri-substituted phenyl Btk inhibitors with improved dual selectivity, a method and a composition for inhibiting Btk and treating disease associated with undesirable Btk activity (Btk-related diseases).

Isolation, Synthesis, and Biological Activity of Chlorinated Alkylresorcinols from Dictyostelium Cellular Slime Molds

Eight chlorinated alkylresorcinols, monochasiol A-H (1-8), were isolated from the fruiting bodies of Dictyostelium monochasioides. Compounds 1-8 were synthesized to confirm their structures and to obtain sufficient material for performing biological tests. Monochasiol A (1) selectively inhibited the concanavalin A-induced interleukin-2 production in Jurkat cells, a human T lymphocyte cell line. Monochasiols were biogenetically synthesized by the combination of biosynthetic enzymes relating to the principal polyketides, MPBD and DIF-1, produced by Dictyostelium discoideum.

POTENT DUAL BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS

Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are also disclosed. In certain aspects, disclosed are compounds of Formula I-IV.