Welcome to LookChem.com Sign In|Join Free

CAS

  • or

22642-82-6

Post Buying Request

22642-82-6 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 6-hydroxy-5-(3-hydroxy-3-oxoprop-1-en-2-yl)oxycyclohexa-1,3-diene-1-carboxylic acid

    Cas No: 22642-82-6

  • No Data

  • No Data

  • No Data

  • BOC Sciences
  • Contact Supplier

22642-82-6 Usage

Description

Isochorismatic acid, also known as 3,4-dihydroxy-5-(3'-methyl-2'-butenyloxy)benzoic acid, is a naturally occurring phenolic compound found in various plant species. It is a derivative of chorismic acid, an important precursor in the biosynthesis of several secondary metabolites, including phenolic compounds and aromatic amino acids. Isochorismatic acid possesses a wide range of biological activities, such as inhibiting tumor cell migration and invasion, exhibiting antioxidant and antibacterial properties, and showing potential in the development of new pharmaceuticals and nutraceuticals. Its unique structure and properties make it a promising candidate for future applications in medical and industrial fields.

Uses

Used in Cancer Treatment:
Isochorismatic acid is used as an anticancer agent for its potent inhibitory effects on tumor cell migration and invasion. It modulates various signaling pathways involved in cancer progression, making it a promising candidate for the treatment of various malignancies.
Used in Antioxidant Applications:
Isochorismatic acid is used as an antioxidant due to its ability to neutralize free radicals and protect cells from oxidative damage. Its antioxidant properties can be utilized in the development of nutraceuticals and health supplements to promote overall health and well-being.
Used in Antibacterial Applications:
Isochorismatic acid is used as an antibacterial agent due to its ability to inhibit the growth of certain bacteria. Its antibacterial properties can be employed in the development of new pharmaceuticals and disinfectants to combat bacterial infections.
Used in Pharmaceutical Development:
Isochorismatic acid is used as a key component in the development of new pharmaceuticals and nutraceuticals. Its wide range of biological activities, including its potential role in cancer treatment, antioxidant, and antibacterial properties, make it a valuable candidate for the development of innovative therapeutic agents.
Used in Industrial Applications:
Isochorismatic acid is used in various industrial applications due to its unique chemical properties. Its potential use in the development of new materials, such as polymers and coatings, can contribute to advancements in various industries, including manufacturing, construction, and textiles.

Check Digit Verification of cas no

The CAS Registry Mumber 22642-82-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,6,4 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 22642-82:
(7*2)+(6*2)+(5*6)+(4*4)+(3*2)+(2*8)+(1*2)=96
96 % 10 = 6
So 22642-82-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H10O6/c1-5(9(12)13)16-7-4-2-3-6(8(7)11)10(14)15/h2-4,7-8,11H,1H2,(H,12,13)(H,14,15)/t7-,8-/m0/s1

22642-82-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name isochorismic acid

1.2 Other means of identification

Product number -
Other names Isochorismic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:22642-82-6 SDS

22642-82-6Relevant articles and documents

The origin of the C-2 hydroxyl in the isochorismate synthase reaction

Gould,Eisenberg

, p. 5979 - 5990 (1991)

Isochorismate synthase has been isolated from Enterobacter aerogenes 62-1 and partially purified through DEAE cellulose chromatography and ammonium sulfate precipitation. When chorismic acid, 8, was treated with this preparation in 50% H21

Genetic and biochemical analyses of chromosome and plasmid gene homologues encoding ICL and ArCP domains in Vibrio anguillarum strain 775

Di Lorenzo, Manuela,Stork, Michiel,Crosa, Jorge H.

experimental part, p. 629 - 643 (2012/04/11)

Anguibactin, the siderophore produced by Vibrio anguillarum 775 is synthesized from 2,3-dihydroxybenzoic acid (DHBA), cysteine and hydroxyhistamine via a nonribosomal peptide synthetase (NRPS) mechanism. Most of the genes encoding anguibactin biosynthetic proteins are harbored by the pJM1 plasmid. In this work we report the identification of a homologue of the plasmid-encoded angB on the chromosome of strain 775. The product of both genes harbor an isochorismate lyase (ICL) domain that converts isochorismic acid to 2,3-dihydro-2,3-dihydroxybenzoic acid, one of the steps of DHBA synthesis. We show in this work that both ICL domains are functional in the production of DHBA in V. anguillarum as well as in E. coli. Substitution by alanine of the aspartic acid residue in the active site of both ICL domains completely abolishes their isochorismate lyase activity in vivo. The two proteins also carry an aryl carrier protein (ArCP) domain. In contrast with the ICL domains only the plasmid encoded ArCP can participate in anguibactin production as determined by complementation analyses and site-directed mutagenesis in the active site of the plasmid encoded protein, S248A. The site-directed mutants, D37A in the ICL domain and S248A in the ArCP domain of the plasmid encoded AngB were also tested in vitro and clearly show the importance of each residue for the domain function and that each domain operates independently.

Effects of macromolecular crowding on the intrinsic catalytic efficiency and structure of enterobactin-specific isochorismate synthase

Jiang, Ming,Guo, Zhihong

, p. 730 - 731 (2007/10/03)

Macromolecular crowding was found to significantly enhance the intrinsic catalytic efficiency of the enterobactin-specific isochorismate synthase by inducing structural change in the enzyme. This finding provides the first experimental evidence that macro

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 22642-82-6