22643-20-5Relevant articles and documents
High-Throughput Screening of Reductive Amination Reactions Using Desorption Electrospray Ionization Mass Spectrometry
Cooks, R. Graham,Ferreira, Christina R.,Li, Yangjie,Logsdon, David L.,Paschoal Sobreira, Tiago Jose,Thompson, David H.
supporting information, p. 1647 - 1657 (2020/10/26)
This study describes the latest generation of a high-throughput screening system that is capable of screening thousands of organic reactions in a single day. This system combines a liquid handling robot with desorption electrospray ionization (DESI) mass spectrometry (MS) for a rapid reaction mixture preparation, accelerated synthesis, and automated MS analysis. A total of 3840 unique reductive amination reactions were screened to demonstrate the throughputs that are capable with the system. Products, byproducts, and intermediates were all monitored in full-scan mass spectra, generating a complete view of the reaction progress. Tandem mass spectrometry experiments were conducted to verify the identity of the products formed. The amine and electrophile reactivity trends represented in the data match what is expected from theory, indicating that the system accurately models the reaction performance. The DESI results correlated well with those generated using more traditional mass spectrometry techniques like liquid chromatography-mass spectrometry, validating the data generated by the system.
Tertiary amine synthesis method
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Paragraph 0052-0057, (2019/01/24)
The invention relates to the technical field of organic matters, and specifically relates to a tertiary amine synthesis method. Under the action of a catalyst, in the absence of solvent and alkali, primary amine, secondary amine, or a nitro derivative reacts with alcohol to prepare tertiary amine. The provided synthesis method has the advantages that no toxic solvent is used during the preparationprocess, the method is green and environmentally friendly, the atom utilization rate is high, the operation is simple, the application range of the functional groups and substrate is wide, and the yield of tertiary amine is high, in particular reactions between aliphatic amine and alcohol.
The invention provides a recyclable waste acid recovery extractant and its preparation method (by machine translation)
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Paragraph 0031; 0032; 0033; 0034; 0035; 0036; 0037; 0038, (2017/02/09)
The present invention provides a kind of recyclable waste acid recovery extractant and its preparation method, the molecular formula of the extractant is R1 R2 NR3 Tertiary amine, in the formula R1 , R2 Are the C8 - C10 straight chain alkane, R3 For the α - ethyl benzene or toluene. The extractant preparation method of alkyl halide, α - methyl benzylamine or benzylamine, catalyst and adding base in the solvent, after heating in backflow, evaporating the solvent, adding water and ethyl acetate extraction, after drying the organic phase is concentrated to get the product. The extractant with the aqueous solution of the present invention low wastage, small pollution to the environment, at the same time the recycling of acid, acid emission reduction, and reduction of environmental pollution. (by machine translation)