22649-37-2

Usage

Uses

Used in Pharmaceutical Synthesis:
1-AMINO-CYCLOPENTANECARBOXYLIC ACID ETHYL ESTER HCL is used as a building block for drug molecules, contributing to the creation of various pharmaceuticals due to its unique structural properties and reactivity.
Used in Organic Synthesis:
In the field of organic synthesis, 1-AMINO-CYCLOPENTANECARBOXYLIC ACID ETHYL ESTER HCL is utilized as an important intermediate, enabling the construction of complex organic molecules for a wide range of applications.
Used in Research and Development:
1-AMINO-CYCLOPENTANECARBOXYLIC ACID ETHYL ESTER HCL is employed in pharmaceutical research for the development of new drugs and therapeutic agents, leveraging its properties to explore novel treatment options and improve existing ones.

Upstream product

• 52-52-8 1-amino-1-cyclopentanecarboxylic acid 
• 110-52-1 1,4-dibromo-butane 
• 64-17-5 ethanol 

Downstream Products

• 93948-00-6 1-N-carbobenzyloxyglycylamino-1-ethoxycarbonylcyclopentane 
• 840506-50-5 phenyl (ethyloxy-L-cyclopentylglycinyl)phosphorochloridate 
• 17193-28-1 1-aminocyclopentane-1-carboxamide 
• 90392-32-8 6,9-diaza-7,10-dioxospiro<4,5>decane 
• 145122-50-5 1-(2,4-difluorophenyl)-6-fluoro-7-(6,9-diazaspiro<4,5>decan-9-yl)-1,4-dihydro-4-oxo<1,8>naphthyridine-3-carboxylic acid trifluoroacetic acid salt 
• 145122-48-1 1-(2,4-difluorophenyl)-6-fluoro-7-(6,9-diazaspiro<4,5>decan-9-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride 
• 145122-71-0 ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(6,9-diazaspiro<4,5>decan-9-yl)-1,4-dihydro-4-oxo<1,8>naphthyridine-3-carboxylate 
• 145122-70-9 ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(6,9-diazaspiro<4,5>decan-9-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 145122-55-0 6,9-diazaspiro<4,5>decane dihydrochloride 

Relevant academic research and scientific papers

SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATIONS AND USES

The present invention relates to polysubstituted imidazolone derivatives, to the pharmaceutical compositions comprising them and to the therapeutic uses thereof in the human and animal health fields. The present invention also relates to a process for preparing these derivatives.

Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-Sulfonamidoisoquinolinyl)guanidines

1-Isoquinolinylguanidines were previously disclosed as potent and selective inhibitors of urokinase-type plasminogen activator (uPA). Further investigation of this template has revealed that incorporation of a 7-sulfonamide group furnishes a new series of potent and highly selective uPA inhibitors. Potency and selectivity can be achieved with sulfonamides derived from a variety of amines and is further enhanced by the incorporation of sulfonamides derived from amino acids. The binding mode of these 1-isoquinolinylguanidines has been investigated by X-ray cocrystallization studies. uPA inhibitor 26 was selected for further evaluation based on its excellent enzyme potency (Ki 10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). In vitro, compound 26 is able to inhibit exogenous uPA in human chronic wound fluid (IC50 = 0.89 μM). In vivo, in a porcine acute excisional wound model, following topical delivery, compound 26 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. On the basis of this profile, compound 26 (UK-371,804) was selected as a candidate for further preclinical evaluation for the treatment of chronic dermal ulcers.

CHEMICAL COMPOUNDS

Phosphoramidate derivatives of nucleotides and their use in the treatment of cancer are described. The base moieties of, for example, each of deoxyuridine, cytarabine, gemcitabine and citidine may be substituted at the 5-position. The phosphoramidate moiety has attached to the P atom an aryl-O moiety and an α-amino acid moiety. The α-amino acid moiety may correspond to or be derived from either a naturally occurring or a non-naturally occurring amino acid.

Wang-aldehyde resin as a recyclable support for the synthesis of α,α-disubstituted amino acid derivatives

Merrifield resin was functionalised with hydroxybenzaldehyde under microwave irradiation. The resultant resin was used as a means for immobilisation and activation of α-amino acid esters for alkylation reactions. α,α-Disubstituted and cyclic amino acid esters were prepared in good yields. The Royal Society of Chemistry 2005.

Composition for the treatment of damaged tissue

A pharmaceutical for use in damaged tissue, such as wound, treatment (e.g. healing) is described. The pharmaceutical comprising a composition which comprises: (a) a growth factor; and (b) an inhibitor agent; and optionally (c) a pharmaceutically acceptable carrier, diluent or excipient; wherein the inhibitor agent can inhibit the action of at least one specific adverse protein (e.g. a specific protease) that is upregulated in a damaged tissue, such as a wound, environment.

Isoquinolines

Isoquinolinylguanidine compounds of formula (I): STR1 wherein the substituents are as defined herein, and salts thereof, are disclosed as urokinase inhibitors.