226569-24-0

Basic information

• Product Name: Carbamic acid, [3-(aminooxy)propyl]-, phenylmethyl ester
• CAS NO: 226569-24-0
• Molecular Formula: C11H16N2O3
• Molecular Weight: 224.26
• Mol File: 226569-24-0.mol

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [3-(aminooxy)propyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [3-(aminooxy)propyl]-, phenylmethyl ester(226569-24-0)
• EPA Substance Registry System: Carbamic acid, [3-(aminooxy)propyl]-, phenylmethyl ester(226569-24-0)

Safety Data

• Hazardous Substances Data: 226569-24-0(Hazardous Substances Data)

Upstream product

• 226569-23-9 N-[3-(Benzyloxycarbonylamino)-1-propoxy]phthalimide 

Downstream Products

• 226569-25-1 N¹-(3-benzyloxycarbonylaminopropoxy)-N²,N³-di-tert-butyloxycarbonylguanidine 

Relevant articles and documents

Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors

The present invention is directed to aminoguanidine and alkoxyguanidine compounds, including compounds of Formula I: wherein X is O or NR19and A1, A2, R7-R10, R18, Ra, Rb/s

Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors

Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: wherein X is O or NR9and Het, R1, R7, R8, R12-R15, Ra, Rb, Rc, Z, and n are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing such compounds. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal, comprising a compound of the invention in a pharmaceutically acceptable carrier. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents. Additionally, the compounds can be detectably labeled and employed for in vivo imaging of thrombi.

Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors

Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: wherein X is O or NR9 and Het, R1, R7, R8, R12-R15, Ra, Rb, Rc, Z, and n are set forth in the specification, as well as hydrates, solvates or pharmaceutica