226571-61-5

Upstream product

• 120711-82-2 4-methyl-6-nitro-3,4-dihydro-2H-1,4-benzoxazine 
• 99-57-0 2-hydroxy-5-nitroaniline 
• 120711-79-7 3,4-dihydro-6-nitro-1,4-benzoxazine-4-carbaldehyde 
• 28226-22-4 6-nitro-1,4-benzoxazine 

Downstream Products

• 120711-72-0 3,4-dihydro-6-(2-imidazolin-2-ylamino)-4-methyl-2H-1,4-benzoxazine hydroiodide 

Relevant academic research and scientific papers

PURINE DERIVATIVES USEFUL AS HSP90 INHIBITORS

The present application provides substituted purine derivatives and related compounds of the formulas shown. These com ounds are useful as inhibitors of HSP90, and hence in the treatment of related diseases. (Formulae) Z1-Z3, Xa-Xc, X2, X4, Y and R are as defined in the specification.

SUBSTITUTED BICYCLIC QUINAZOLIN-4-YLAMINE DERIVATIVES

Substituted bicyclic quinazolin-4-ylamine derivatives are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with patholog

Imidiazoles having reduced side effects

Methods and compounds for the treatment of conditions including pain, particularly chronic pain, glaucoma or elevated intraocular pressure with reduced cardiovascular or sedative side effects. Also included are methods of making and using such compounds.

Heteroaromatic Analogues of the α2-Adrenoreceptor Partial Agonist Clonidine

A 1,4-dioxane analogue (1) of the α2-adrenoreceptor partial agonist clonidine (2) has previously been shown to possess an interesting but complex pharmacological profile.In this study, from a series of other heterocyclic analogues of clonidine,