226719-38-6

Basic information

• Product Name: (2E,4E)-5-m-Tolyl-penta-2,4-dienoic acid
• CAS NO: 226719-38-6
• Molecular Weight: 188.226
• Mol File: 226719-38-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2E,4E)-5-m-Tolyl-penta-2,4-dienoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2E,4E)-5-m-Tolyl-penta-2,4-dienoic acid(226719-38-6)
• EPA Substance Registry System: (2E,4E)-5-m-Tolyl-penta-2,4-dienoic acid(226719-38-6)

Safety Data

• Hazardous Substances Data: 226719-38-6(Hazardous Substances Data)

Upstream product

• 623-43-8 methyl crotonate 
• 620-23-5 m-tolyl aldehyde 

Downstream Products

• 105401-68-1 5-(m-tolyl)pentanoic acid 

Relevant articles and documents

Stereochemical considerations and the antiinflammatory activity of 6-amino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ols and related derivatives

The antiinflammatory activity of a series of 6-amino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ols and related derivatives were examined using the reverse passive Arthus reaction (RPAR). The antiinflammatory activity of these compounds was markedly influenced by the stereochemistry of the amino alcohol moiety. The threo diastereomer exhibited activity in the RPAR, while the erythro diastereomer was devoid of any significant antiinflammatory activity. The antiinflammatory activity of the amino alcohols was also significantly influenced by the position and nature of the aromatic substituent. Latentiation of the amino alcohol function resulted in analogues exhibiting antiinflammatory activity equivalent to their amino alcohol precursors. Masking the amino alcohol function as a more stable derivative led to analogues exhibiting an antiinflammatory profile unique to their structural class.