22676-36-4Relevant academic research and scientific papers
Selenium polymer prodrug micelle with reduction responsiveness, preparation method and application
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Paragraph 0063; 0065; 0069-0070; 0077; 0080; 0084; 0087, (2020/11/02)
The invention discloses a selenium polymer prodrug micelle with reduction responsiveness, a preparation method and application, and belongs to the technical field of biological medicine. The micelle is prepared by applying the following selenium prodrug polymer; the selenium prodrug polymer has a structure as shown in a formula (I); according to the invention, by using vorinostat as a model, firstly, a vorinostat derivative containing a di-selenium bond is synthesized, then hydrophilic fragments polyethylene glycol are connected to both ends of the derivative, and then the obtained product isprepared into the nano micelle, so that a drug is stable in a body, and a histone deacetylase inhibiting effect is obviously improved; and the preparation method is simple, convenient, green and environmental-friendly, and has the potential of mass production.
