2268-16-8

Usage

Chemical Properties

white crystalline powder or chunks

InChI:InChI=1/C6H3F3O/c7-3-1-5(9)6(10)2-4(3)8/h1-2,10H

Upstream product

• 367-34-0 2,4,5-trifluoroaniline 
• 327-54-8 1,2,4,5-Tetrafluorobenzene 
• 652-18-6 2,3,5,6-tetrafluorobenzoic acid 

Downstream Products

• 2267-67-6 3-(2,4,5-trifluoro-phenoxy)-propionic acid 
• 325-81-5 (2,4,5-trifluorophenoxy)acetic acid 
• 100231-56-9 2,3,7,8-tetrafluorodibenzodioxin 
• 937817-45-3 (2,4,5-trifluorophenoxy)acetic acid tert-butyl ester 
• 5006-38-2 1,2,4-trifluoro-5-methoxybenzene 
• 1532534-26-1 1-(2,4-dihydroxy-5-methylphenyl)-2-(2,4,5-trifluorophenoxy)ethanone 
• 1532534-06-7 2-(2,4,5-trifluorophenoxy)-1-(2,4,6-trihydroxyphenyl)ethanone 
• 1532533-54-2 1-(5-ethyl-2,4-dihydroxyphenyl)-2-(2,4,5-trifluorophenoxy)ethanone 
• 1532534-92-1 C₈H₄F₃NO 
• 1418095-90-5 C₆H₃F₃O*C₂₅H₃₅NO 
• 1418095-58-5 C₆H₃F₃O*C₁₇H₁₉NO 
• 1196484-77-1 4-[3-methyl-4-(2,4,5-trifluoro-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid isopropyl ester 
• 1196484-98-6 4-[4-(2,4,5-trifluoro-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester 
• 200887-53-2 Tl⁽¹⁺⁾*C₆H₂F₃O^(1-)=TlOC₆H₂F₃ 

Relevant academic research and scientific papers

Synthesis method of fluorine-containing phenol structure compound

The invention discloses a synthesis method of a fluorine-containing phenol structure compound, and belongs to the technical field of chemical synthesis. Fluorine-containing benzoic acid is subjected to a one-pot reaction in a solvent under the action of alkali to obtain fluorine-containing phenate, and fluorine-containing phenol is obtained after acid regulation and dissociation. The synthesis method has the advantages of rich, cheap and easily available raw material structure, short synthesis steps, mild reaction conditions, simple and convenient operation, high synthesis yield, good productquality, wide application range and the like, and is suitable for simple and efficient synthesis of various high-value and high-purity fluorine-containing phenol compounds.

Homolytic Reactions of Polyfluoroaromatic Compounds. Part 16. Competitive Phenylation of Polyfluorobenzenes

Pairs of polyfluorobenzenes were allowed to compete for phenyl radicals generated by thermolysis of benzoyl peroxide at 80 deg C.From the relative yields of biaryl, and the yields of each biaryl formed upon arylation of each arene individually, the relative rates of attack of each site in each arene were deduced.Neither iron(III) benzoate nor trichloroacetic acid uniformly improved yields of biaryl, although in some cases the isomer distribution altered, when decomposition of benzoyl peroxide was carried out in the presence of such additives, to favour products of aryldehydrogenation or of aryldefluorination, respectively.Competition did not usually affect the distribution of attack of a particular arene, except when hexafluorobenzene was used, in which case greater selectivity of attack of the second arene occured.This suggested the formation of a 'stabilised' phenyl radical, and supported an earlier suggestion of species such as >; other evidence also supported the postulate.