22687-07-6Relevant academic research and scientific papers
Modified N,O-nucleosides: Design, synthesis, and anti-tumour activity
Maiuolo, Loredana,Bortolini, Olga,De Nino, Antonio,Russo, Beatrice,Gavioli, Riccardo,Sforza, Fabio
, p. 670 - 674 (2014/05/06)
A preliminary library of modified N,O-nucleosides was prepared and tested on a selected number of human cancer lines that include SKOV3, SW480, and K562. Thymine, N-benzyl substituents, and aromatic rings contribute to an increase of the biological activity, up to 10-25μM, that appeared also reliant on the calculated lipophilicity of the nucleosides, expressed as cLogP, where P represents the partition coefficient of a solute between n-octanol and water. CSIRO 2014.
Efficient synthesis of isoxazolidine-substituted bisphosphonates by 1,3-dipolar cycloaddition reactions
Bortolini,Mulani,De Nino,Maiuolo,Nardi,Russo,Avnet
experimental part, p. 5635 - 5641 (2011/08/22)
Several bisphosphonates bearing a substituted isoxazolidine ring have been synthesized in good yield by direct 1,3-dipolar cyclization reaction, under microwaves catalysis, in the absence of solvent. The method allows the simultaneous incorporation, on the geminal position of the bisphosphonate framework, of a basic nitrogen and of an oxygen atom, as third hook. Hydrophobicity-hydrophilicity of BPs is discussed with the help of distribution coefficients.
