226895-52-9Relevant academic research and scientific papers
Synthesis of fused indoles by sequential palladium-catalyzed Heck reaction and N-heteroannulation
S?derberg, Bj?rn C.G.,Hubbard, Jeremiah W.,Rector, Stacey R.,O'Neil, Shannon N.
, p. 3637 - 3649 (2007/10/03)
A route to 3,4-fused indoles via two consecutive palladium-catalyzed reactions; an intramolecular Heck reaction followed by a reductive N-heteroannulation is described. Using this route, a number of indoles have been prepared having a variety of ring sizes anchored to the 3- and 4-position of the indole nucleus. Furthermore, a number of functional groups, both carbon and heteroatom substituents can be introduced in (and on) the additional ring without any detrimental effects on the two reactions.
Palladium-catalyzed synthesis of fused indoles
Soederberg, Bjoern C.,Rector, Stacey R.,O'Neil, Shannon N.
, p. 3657 - 3660 (2007/10/03)
A novel route to fused indoles via two consecutive palladium catalyzed reactions, an intramolecular Heck reaction followed by a reductive N- heteroannulation, has been developed. For example, reaction of 2-bromo-3- nitro-1(3-butenyloxy)benzene with pallad
