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226904-00-3

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226904-00-3 Usage

Biological Activity

lansoprazole sodium is a proton-pump inhibitor (ppi) and also can inhibit cytochrome p450 [1].lansoprazole sodium is a substituted benzimidazole and has been widely used as acid inhibitory agent for treatment of disorders related to gastric acid secretion. lansoprazole sodium has been exhibited to inhibit stomach acid by blocking the h+/k+atpase system at the secretory surface of gastric parietal cells. as the human p450 enzymes including cyp2c9,2c19, 2d6 and 3a4, in addition, lansoprazole sodium has been reported to have the competitively inhibitory effect on the activity of cyp2c9 in hlm with a ki value of 21μm. lansoprazole sodium has been found to be potent cyp2c19 inhibitor with a ki value of about 1μm in both hlm and rcyp2c19 tests. besides, lansoprazole sodium has been revealed to inhibit the activities if cyp2d6 and cyp3a4 with ic50 values of both>200μm [1].

references

[1] li xq1, andersson tb, ahlstr?m m, weidolf l.comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome p450 activities. drug metab dispos. 2004 aug;32(8):821-7.

Check Digit Verification of cas no

The CAS Registry Mumber 226904-00-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,6,9,0 and 4 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 226904-00:
(8*2)+(7*2)+(6*6)+(5*9)+(4*0)+(3*4)+(2*0)+(1*0)=123
123 % 10 = 3
So 226904-00-3 is a valid CAS Registry Number.

226904-00-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name sodium,2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]benzimidazol-1-ide

1.2 Other means of identification

Product number -
Other names UNII-GV9NY1U369

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:226904-00-3 SDS

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