226910-85-6Relevant academic research and scientific papers
Process for preparing optically active 3-azidocarboxylic acid derivatives and 3-aminocarboxylic acid derivatives
-
Page/Page column 8-10, (2008/06/13)
A process for enantioselectively preparing 3-azidocarboxylic acid derivatives comprises reacting 3-sulfonatocarboxylic acid derivatives with an alkali metal azide in a solvent selected from the group comprising certain carboxamides; a solvent mixture which comprises such carboxamides; a solvent mixture of water and a solvent miscible homogeneously with water; water with the proviso that the addition of a phase transfer catalyst is not used in the reaction in water; and DMSO. The resulting products are optionally reduced to 3-aminocarboxylic acid derivatives.
