226915-81-7Relevant academic research and scientific papers
Himbacine derived thrombin receptor antagonists: Discovery of a new tricyclic core
Clasby, Martin C.,Chackalamannil, Samuel,Czarniecki, Michael,Doller, Dario,Eagen, Keith,Greenlee, William J.,Lin, Yan,Tagat, Jayaram R.,Tsai, Hsingan,Xia, Yan,Ahn, Ho-Sam,Agans-Fantuzzi, Jacqueline,Boykow, George,Chintala, Madhu,Hsieh, Yunsheng,McPhail, Andrew T.
, p. 3647 - 3651 (2008/02/07)
The synthesis and biological activity of a novel series of thrombin receptor antagonists is described. This series of compounds showed excellent in vitro and in vivo potency. The most potent compound 40 had an IC50 of 7.6 nM and showed robust i
THROMBIN RECEPTOR ANTAGONISTS
-
Page 76, (2010/11/30)
Heterocyclic-substituted tricyclics of formula (I) or a pharmaceutically acceptable salt thereof, wherein: the single dotted line represents an optional double bond; the double dotted line represents an optional single bond; n is 0-2; Q is optionally subs
A facile Diels-Alder route to dihydronaphthofuranones
Chackalamannil, Samuel,Doller, Darío,Clasby, Martin,Xia, Yan,Eagen, Keith,Lin, Yan,Tsai, Hsing-An,McPhail, Andrew T.
, p. 4043 - 4047 (2007/10/03)
An efficient, multigram-scale synthesis of dihydronaphthofuranone 1 using a novel aryl intramolecular Diels-Alder reaction of propargyl trans- cinnamate 8 is described. Catalytic reduction of 1 gave the cis-fused tetrahydronaphthofuranone derivative 2. (C) 2000 Elsevier Science Ltd.
