226922-01-6Relevant academic research and scientific papers
Efficient tin hydride-mediated radical cyclisation of secondary amides leading to substituted pyrrolidinones. Part 2. Application to the synthesis of aromatic kainic acid analogues
Bryans, Justin S.,Large, Jonathan M.,Parsons, Andrew F.
, p. 2905 - 2910 (2007/10/03)
An enantioselective synthesis of phenyl allokainoid, starting from D-serine, is reported. Tin-mediated cyclisation of a secondary amide was used in the key step to produce a trisubstituted pyrrolidinone in excellent yield (ca. 80%). The predominant format
Efficient radical cyclisation of secondary amides: An enantioselective synthesis of phenyl allokainoid
Bryans, Justin S.,Large, Jonathan M.,Parsons, Andrew F.
, p. 3487 - 3490 (2007/10/03)
Cyclisation of various unsaturated haloamides with tributyltin hydride/AIBN has been explored. Substituted pyrrolidinones were isolated in good to excellent yield and the cyclisation of a serine-derived amide was utilised as the key step in an enantiosele
