226922-99-2

Upstream product

• 2845-62-7 benzenesulphonyl isocyanate 
• 226922-93-6 4-amino-3,4-dihydro-2,2-dimethyl-6-fluoro-(2H)-1-benzopyran 
• 371-41-5 4-Fluorophenol 
• 405-51-6 4-fluorophenyl acetate 
• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 105799-73-3 6-fluoro-2,2-dimethyl-chroman-4-one 
• 132686-72-7 6-fluoro-2,2-dimethyl-chroman-4-ol 
• 226922-88-9 4-(N-acetylamino)-3,4-dihydro-2,2-dimethyl-6-fluoro-2H-1-benzopyran 

Relevant academic research and scientific papers

Synthesis and pharmacological evaluation of K(ATP)-channel openers related to cromakalim: Introduction of arylsulphonylurea moieties

A series of 4-(arylsulphonylaminocarbonylamino)-3,4-dihydro-2,2-dimethyl-2 H-1-benzopyran derivatives were prepared and evaluated as potential ATP-sensitive potassium-channel activators. Pharmacological studies showed that some compounds expressed vasodilator efficacy on vascular smooth muscle. The compounds had no inhibitory activity on insulin secretion from pancreatic β-cells.