226930-78-5Relevant academic research and scientific papers
Pyrrole derivatives useful for farnesyl transferase inhibitors and their preparations
-
, (2008/06/13)
The present invention relates to a novel pyrrole derivative which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof; to a process for preparation of said compound; and to a pharmaceutical composition such as anti-cancer composition, etc. comprising said compound as an active ingredient together with pharmaceutically acceptable carrier.
Efficient synthesis of 1-substituted-5-hydroxymethylimidazole derivatives: Clean oxidative cleavage of 2-mercapto group
Hyok Chang, Jay,Woong Lee, Kyu,Hyun Nam, Do,Sup Kim, Won,Shin, Hyunik
, p. 674 - 676 (2013/09/06)
1-Substituted-5-hydroxymethylimidazoles were prepared through green desulfurization of their 2-mercapto derivatives by the treatment of 30% hydrogen peroxide in the presence of a catalytic amount of transition metal catalysts.
Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof
-
, (2008/06/13)
The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n1and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.
