226931-62-0Relevant articles and documents
3-Aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrrole, a novel class of farnesyltransferase inhibitors
Lee, Hyunil,Lee, Jinho,Shin, Youseung,Jung, Wonhee,Kim, Jong-Hyun,Park, Kiwon,Ro, Seonggu,Chung, Hyun-Ho,Koh, Jong Sung
, p. 2963 - 2965 (2001)
Design, synthesis and structure-activity relationship of a class of 3-aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrroles as farnesyltransferase inhibitors are described. Compound 7 inhibits farnesyltransferase with an IC50 value of 4.6 nM.