226935-97-3

Upstream product

• 14098-44-3 2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-benzopentaoxacyclopentadecin 
• 5707-04-0 Phenylselenyl chloride 
• 73750-24-0 1-(2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-benzopentaoxacyclopentadecin-15-yl)-1-propanone 

Downstream Products

• 226936-01-2 4-<3(2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-benzopentaoxacyclopentadecin-15-yl)-4,5-dihydro-1H-pyrazol-1-yl>benzoic acid 

Relevant academic research and scientific papers

Synthesis and characterisation of new fluorescent Na+ and K+ indicators

The synthesis of new fluorescent indicators for Na+, Benz-15-5 or Diaz- 15-5, and for K+, Benz-18-6 or Diaz-18-6, respectively, is reported. They consist of a benzocrown or a diazacrown ether linked to a pyrazoline fluorophore substituted with carboxylate groups to ensure water solubility. They were obtained via reaction of an α,β-unsaturated ketone with an aryl hydrazine. The fluorescence intensity of Benz-15-5 is nearly insensitive to Na+. Benz- 18-6 displays a four-fold selectivity for K+ over Na+, with a dissociation constant of 3.6 mM for the K+: indicator complex. Diaz-15-5 and Diaz-18-6 have only a weak affinity for monovalent cations, so that they only can be used for the determination of high Na+ and K+ concentrations.