226936-40-9

Upstream product

• 226936-28-3 7,16-bis<4-(1-oxopropyl)phenyl>-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane 
• 23978-55-4 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane 
• 456-03-1 1-(4-fluorophenyl)propan-1-one 
• 226936-34-1 7,16-bis<4-(1-oxo-2-phenylselenylpropyl)phenyl>-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane 

Downstream Products

• 226936-47-6 7,16-bis<4-<1-(3,5-dimethoxycarbonyl)phenyl-4,5-dihydro-1H-pyrazol-3-yl>phenyl>-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane 

Relevant academic research and scientific papers

Synthesis and characterisation of new fluorescent Na+ and K+ indicators

The synthesis of new fluorescent indicators for Na+, Benz-15-5 or Diaz- 15-5, and for K+, Benz-18-6 or Diaz-18-6, respectively, is reported. They consist of a benzocrown or a diazacrown ether linked to a pyrazoline fluorophore substituted with carboxylate groups to ensure water solubility. They were obtained via reaction of an α,β-unsaturated ketone with an aryl hydrazine. The fluorescence intensity of Benz-15-5 is nearly insensitive to Na+. Benz- 18-6 displays a four-fold selectivity for K+ over Na+, with a dissociation constant of 3.6 mM for the K+: indicator complex. Diaz-15-5 and Diaz-18-6 have only a weak affinity for monovalent cations, so that they only can be used for the determination of high Na+ and K+ concentrations.