226940-44-9

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 20949-84-2 2-methylthiazole-4-carbaldehyde 
• 226940-38-1 tert-butyl-dimethyl-(2-methyl-hept-6-enyloxy)-silane 
• 190369-75-6 (S)-6-(tert-Butyl-dimethyl-silanyloxy)-5-methyl-hexanal 
• 188730-01-0 6-tert-butyldimethylsilyloxy-5-methylhexan-1-ol 
• 188730-03-2 6-tert-butyldimethylsilyloxy-1-iodo-5-methylhexane 
• 226940-40-5 (S)-7-(tert-butyl-dimethyl-silanyloxy)-6-methyl-2-(triphenylphosphanylidene)-heptanoic acid methyl ester 
• 252986-94-0 (E)-(S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-(2-methyl-thiazol-4-yl)-hex-5-ene-1,2-diol 
• 226940-36-9 4-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-hexa-1,5-dienyl]-2-methyl-thiazole 
• 226940-37-0 (3S,4E)-5-(2-methylthiazol-4-yl)-3-(tert-butyl-dimethylsilyloxy)-4-pentenal 
• 226940-35-8 (E)-(S)-1-(2-Methyl-thiazol-4-yl)-hexa-1,5-dien-3-ol 
• 226940-34-7 (2E)-3-(2-Methylthiazol-4-yl)-2-propenal 
• 76-83-5 trityl chloride 
• 226940-43-8 4-[(1E,5E)-(3S,10S)-3,11-Bis-(tert-butyl-dimethyl-silanyloxy)-10-methyl-6-trityloxymethyl-undeca-1,5-dienyl]-2-methyl-thiazole 

Downstream Products

• 226940-45-0 (6E,10E)-(2S,9S)-9-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-11-(2-methyl-thiazol-4-yl)-6-trityloxymethyl-undeca-6,10-dienal 

Relevant academic research and scientific papers

Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues

The macrolactonization-based strategy for the total synthesis of epothilones has been streamlined and improved to a high level of efficiency and stereoselectivity. This strategy has been applied to the construction of vinyl iodide 19 which served as a com

Synthesis of 16-desmethylepothilone B: Improved methodology for the rapid, highly selective and convergent construction of epothilone B and analogues

During a synthesis of 16-desmethylepothilone B new methods for the convergent and highly stereoselective synthesis of epothilone B and analogues were developed.