226940-68-7

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 226940-62-1 (3S,4E)-3-[(tert-butyldimethylsilyl)oxy]-5-iodo-4-methylpent-4-enal 
• 226940-38-1 tert-butyl-dimethyl-(2-methyl-hept-6-enyloxy)-silane 
• 190369-75-6 (S)-6-(tert-Butyl-dimethyl-silanyloxy)-5-methyl-hexanal 
• 188730-01-0 6-tert-butyldimethylsilyloxy-5-methylhexan-1-ol 
• 188730-03-2 6-tert-butyldimethylsilyloxy-1-iodo-5-methylhexane 
• 240815-94-5 [(6E,10E)-(2S,9S)-9-(tert-Butyl-dimethyl-silanyloxy)-11-iodo-2,10-dimethyl-6-trityloxymethyl-undeca-6,10-dien-(E)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine 
• 240815-93-4 tert-Butyl-[(E)-(S)-7-iodo-1-((E)-2-iodo-1-methyl-vinyl)-4-trityloxymethyl-hept-3-enyloxy]-dimethyl-silane 
• 240815-92-3 (4E,8E)-(S)-7-(tert-Butyl-dimethyl-silanyloxy)-9-iodo-8-methyl-4-trityloxymethyl-nona-4,8-dien-1-ol 
• 240815-91-2 tert-Butyl-[(E)-(S)-1-((E)-2-iodo-1-methyl-vinyl)-4-trityloxymethyl-hepta-3,6-dienyloxy]-dimethyl-silane 
• 240815-89-8 (2E,6E)-(S)-2-Allyl-5-(tert-butyl-dimethyl-silanyloxy)-7-iodo-6-methyl-hepta-2,6-dienoic acid methyl ester 
• 240815-90-1 (2E,6E)-(S)-2-Allyl-5-(tert-butyl-dimethyl-silanyloxy)-7-iodo-6-methyl-hepta-2,6-dien-1-ol 
• 240816-27-7 (4S,5E)-4-[(tert-Butyldimethylsilyl)oxy]-6-iodo-5-methylhex-5-ene-1,2-diol 
• 240815-88-7 (-)-tert-butyl-(S)-{1-[(E)-2-iodo-1-methylvinyl]-but-3-enyloxy}-dimethylsilane 

Downstream Products

• 240815-96-7 (12E,16E)-(3S,6R,7S,8S,15S)-1,3,15-Tris-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-17-iodo-4,4,6,8,16-pentamethyl-12-trityloxymethyl-heptadeca-12,16-dien-5-one 
• 240815-98-9 (12E,16E)-(3S,6R,7S,8S,15S)-1,3,7,15-Tetrakis-(tert-butyl-dimethyl-silanyloxy)-17-iodo-4,4,6,8,16-pentamethyl-12-trityloxymethyl-heptadeca-12,16-dien-5-one 
• 240816-03-9 (E)-(4S,7R,8S,9S,16S)-4,8-Bis-(tert-butyl-dimethyl-silanyloxy)-16-((E)-2-iodo-1-methyl-vinyl)-5,5,7,9-tetramethyl-13-trityloxymethyl-oxacyclohexadec-13-ene-2,6-dione 
• 240816-02-8 (12E,16E)-(3S,6R,7S,8S,15S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-15-hydroxy-17-iodo-4,4,6,8,16-pentamethyl-5-oxo-12-trityloxymethyl-heptadeca-12,16-dienoic acid 
• 240816-00-6 (12E,16E)-(3S,6R,7S,8S,15S)-3,7,15-Tris-(tert-butyl-dimethyl-silanyloxy)-17-iodo-4,4,6,8,16-pentamethyl-5-oxo-12-trityloxymethyl-heptadeca-12,16-dienal 
• 240815-99-0 (12E,16E)-(3S,6R,7S,8S,15S)-3,7,15-Tris-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-17-iodo-4,4,6,8,16-pentamethyl-12-trityloxymethyl-heptadeca-12,16-dien-5-one 
• 240816-01-7 (12E,16E)-(3S,6R,7S,8S,15S)-3,7,15-Tris-(tert-butyl-dimethyl-silanyloxy)-17-iodo-4,4,6,8,16-pentamethyl-5-oxo-12-trityloxymethyl-heptadeca-12,16-dienoic acid 

Relevant academic research and scientific papers

Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues

The macrolactonization-based strategy for the total synthesis of epothilones has been streamlined and improved to a high level of efficiency and stereoselectivity. This strategy has been applied to the construction of vinyl iodide 19 which served as a com

Synthesis of 16-desmethylepothilone B: Improved methodology for the rapid, highly selective and convergent construction of epothilone B and analogues

During a synthesis of 16-desmethylepothilone B new methods for the convergent and highly stereoselective synthesis of epothilone B and analogues were developed.

Total synthesis of Epothilone E and related side-chain modified analogues via a stille coupling based strategy

A Stille coupling strategy has been utilized to complete a total synthesis of epothilone E from vinyl iodide 7 and thiazole-stannane 8h. The central core fragment 7 and its trans-isomer 11 were prepared from triene 15 using ring-closing metathesis (RCM),