226958-72-1Relevant academic research and scientific papers
Selective N-dealkylation of tertiary amines derived from phenylglycinol or ephedrine family
Agami, Claude,Couty, Francois,Evano, Gwilherm
, p. 3709 - 3712 (1999)
Tertiary mines bearing an hydroxyethyl group derived from phenylglycinol, norephedrine or norpseudoephedrine can be selectively dealkylated using a two-step sequence involving treatment with thionyl chloride in THF, followed by reaction with an excess of potassium cyanide in THF:DMSO. These conditions are compatible with the presence of an insaturation or a benzyl ether in the substrate.
