227002-09-7

Upstream product

• 105539-79-5 1(R)-4-exo-(benzoyloxy)-1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-6-oxabicyclo<3.2.1>oct-2-en-7-one 

Downstream Products

• 639806-78-3 methyl (1R,3R,4R)-3,4-dihydroxy-1-(4'-nitrobenzyloxy)cyclohex-5-en-1-carboxylate 
• 639806-80-7 methyl (1R,3R,4R)-3,4-dihydroxy-1-(2'-nitrobenzyloxy)cyclohex-5-en-1-carboxylate 
• 639806-76-1 (1R,3R,4R)-4-benzyloxy-1-(4'-nitrobenzyloxy)cyclohex-5-en-1,3-carbolactone 
• 639806-77-2 (1R,3R,4R)-4-benzyloxy-1-(2'-nitrobenzyloxy)cyclohex-5-en-1,3-carbolactone 

Relevant academic research and scientific papers

Synthesis of carba-sugars from (-)-quinic acid

(1S,2R,3R,4S,5R)- (3a) and (1S,2S,3S,4S,5R)-1,2,3,4,5-pentahydroxy-1-hydroxymethylcyclohexane (4a), (1R,2R,3R,4S,5R)- (3b) and (1R,2S,3S,4S,5R)-1,2,3,4,5-pentahydroxycyclohexan-1-carboxylic acid (4b) are reported. The syntheses exploit the diastereoselective oxidation of the 5,6-double bond of the quinic acid-derived lactone 2 with osmium tetroxide.

METHOD OF OBTAINING INHIBITORS OF TYPE II DEHYDROQUINASE ENZYME AND PRECURSORS THEREOF

The present invention relates to a process of obtaining type II dehydroquinase enzyme inhibitors and the precursors thereof from (-)-quinic acid. The described compounds have a carboxycyclohexene structure. The process of preparing the compounds and their

Parallel Solid-Phase Synthesis and Evaluation of Inhibitors of Streptomyces coelicolor Type II Dehydroquinase

A series of 1-substituted and 4-substituted benzyl analogues of the known inhibitor (1S,3R,4R)-1,3,4-trihydroxy-5-cyclohexene-1-carboxylic acid has been synthesized and tested as inhibitors of Streptomyces coelicolor type II dehydroquinase. The solid-phas