227002-09-7Relevant articles and documents
Synthesis of carba-sugars from (-)-quinic acid
Carballido, Montserrat,Castedo, Luis,González, Concepción
, p. 3973 - 3976 (2001)
(1S,2R,3R,4S,5R)- (3a) and (1S,2S,3S,4S,5R)-1,2,3,4,5-pentahydroxy-1-hydroxymethylcyclohexane (4a), (1R,2R,3R,4S,5R)- (3b) and (1R,2S,3S,4S,5R)-1,2,3,4,5-pentahydroxycyclohexan-1-carboxylic acid (4b) are reported. The syntheses exploit the diastereoselective oxidation of the 5,6-double bond of the quinic acid-derived lactone 2 with osmium tetroxide.
METHOD OF OBTAINING INHIBITORS OF TYPE II DEHYDROQUINASE ENZYME AND PRECURSORS THEREOF
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Page/Page column 15-16, (2008/06/13)
The present invention relates to a process of obtaining type II dehydroquinase enzyme inhibitors and the precursors thereof from (-)-quinic acid. The described compounds have a carboxycyclohexene structure. The process of preparing the compounds and their
Parallel Solid-Phase Synthesis and Evaluation of Inhibitors of Streptomyces coelicolor Type II Dehydroquinase
González-Bello, Concepción,Lence, Emilio,Toscano, Miguel D.,Castedo, Luis,Coggins, John R.,Abell, Chris
, p. 5735 - 5744 (2007/10/03)
A series of 1-substituted and 4-substituted benzyl analogues of the known inhibitor (1S,3R,4R)-1,3,4-trihydroxy-5-cyclohexene-1-carboxylic acid has been synthesized and tested as inhibitors of Streptomyces coelicolor type II dehydroquinase. The solid-phas