22701-42-4

Usage

Uses

Used in Pharmaceutical Research:
(2-PYRIDIN-2-YL-ETHYLSULFANYL)-ACETIC ACID is used as a building block for the development of new drugs and medicinal compounds due to its unique structure and properties.
Used in Organic Synthesis:
(2-PYRIDIN-2-YL-ETHYLSULFANYL)-ACETIC ACID is used as a reagent in chemical reactions, contributing to the synthesis of more complex molecules.
Used in Chemical Reactions:
(2-PYRIDIN-2-YL-ETHYLSULFANYL)-ACETIC ACID serves as a precursor to other complex molecules, playing a crucial role in advancing the field of organic chemistry.

Upstream product

• 2044-28-2 (pyridyl-2)-2 ethanethiol 
• 79-11-8 chloroacetic acid 
• 100-69-6 2-vinylpyridine 
• 68-11-1 mercaptoacetic acid 

Relevant academic research and scientific papers

Rhenium(I) and Technetium(I) tricarbonyl complexes with [NSO]-type chelators: Synthesis, structural characterization, and radiochemistry

The reactions of the NSO ligands 2-[2-(pyridin-2-yl)ethylthio]acetic acid (HL1), 3-[2-(pyridin-2-yl)ethylthio]propanoic acid (HL2), 2-(carboxymethylthio)- 3-(1H-imidazol-4-yl)propanoic acid (H2L3), and 2-(carboxyethylthio)- 3-(1H-imidazol-4-yl)propanoic acid (H2L4) with [NEt4] 2[ReBr3(CO)3] are presented. Ligands HL1, H2L3, and H2L4 act as tridentate NSO chelators and readily generate the fac-[Re(NSO)(CO)3]complexes Re-L1, Re-HL3, and Re-HL4. Ligand HL2 acts as NSO tridentate chelator only in the presence of base to give complex Re-L2, while without base it coordinates as a NS bidentate chelator to generate complex fac-[ReBr(NS)(CO)3], Re-HL2. All complexes were isolated and characterized by elemental analysis, IR and 1H, 13C NMR spectroscopy. Complex Re-L1, Re-HL2, and Re-HL3 were characterized also by X-ray crystallography. Furthermore, the analogous technetium complexes fac-[99mTc(NSO)(CO)3]+, 99mTc-L1, 99mTc-L2, 99mTc-HL3, and 99mTc-HL4 were synthesized by reacting ligands HL1-H2L4 with the fac-[99mTc(OH2)3(CO)3] + precursor for 30 min at 75 °C. The tracer complexes 99mTc-L1-99mTc-HL4 were found to be stable in L-cysteine and L-histidine challenge experiments. The bifunctional chelating agents that bear a second carboxylate group are promising for the development of targeted 99mTc radiopharmaceuticals.

Macrolides with antibacterial activity

The invention provides new macrolides antibiotics of formula (I) with improved biological properties and improved stability formula (I): wherein R1 is hydrogen, cyano, —S(L)mR2, —S(O)(L)mR2, or —S(O)