22704-51-4

Basic information

• Product Name: 1H-Benzimidazol-2-amine,N,N-dimethyl-5-methyl-(9CI)
• Synonyms: 1H-Benzimidazol-2-amine,N,N-dimethyl-5-methyl-(9CI)
• CAS NO: 22704-51-4
• Molecular Formula: C10H13N3
• Molecular Weight: 175.23032
• Product Categories: BENZIMIDAZOLE
• Mol File: 22704-51-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 319.5°Cat760mmHg
• Flash Point: 147°C
• Appearance: /
• Density: 1.173g/cm³
• Vapor Pressure: 0.000338mmHg at 25°C
• Refractive Index: 1.669
• CAS DataBase Reference: 1H-Benzimidazol-2-amine,N,N-dimethyl-5-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazol-2-amine,N,N-dimethyl-5-methyl-(9CI)(22704-51-4)
• EPA Substance Registry System: 1H-Benzimidazol-2-amine,N,N-dimethyl-5-methyl-(9CI)(22704-51-4)

Safety Data

• Hazardous Substances Data: 22704-51-4(Hazardous Substances Data)

Usage

Chemical family

benzimidazole

Derivative

N,N-dimethyl and 5-methyl substituents

Common uses

building block for the synthesis of bioactive molecules in pharmaceutical research

Potential applications

antifungal, antiviral, and anticancer agent

Chemical structure

valuable intermediate for the development of new drugs and therapies

Pharmacological and toxicological properties

still under investigation

InChI:InChI=1/C10H13N3/c1-7-4-5-8-9(6-7)12-10(11-8)13(2)3/h4-6H,1-3H3,(H,11,12)

Relevant articles and documents

Method for catalytic synthesis of benzimidazole derivative from N,N-dimethylthiocarbamoyl chloride derivative under microwave radiation

The invention discloses a method for catalytic synthesis of benzimidazole derivative under microwave radiation. The method comprises steps as follows: the catalytic quantities of a catalyst cuprous iodide, an aided catalyst sodium hydroxide, o-phenylenediamine, a derivative of o-phenylenediamine and an N,N-dimethylthiocarbamoyl chloride derivative are added to a reaction vessel and taken as raw materials, a pyridine solvent is added, all materials are placed in a microwave reaction instrument and subjected to a reaction at certain temperature and power, after a period of time, reduced-pressureconcentration is performed, and a product is subjected to column chromatography purification. The efficient method which adopts the novel raw materials and is simple and convenient to operate and used for preparing the benzimidazole derivative is provided. Compared with the prior art, the method has the advantages of being simple to operate, high in yield, safe, low in cost and environmentally friendly, reaction speed is obviously higher than that of conventional heating, and reaction conditions are mild.