22706-01-0Relevant articles and documents
Synthesis of Structurally Diverse Benzotriazoles via Rapid Diazotization and Intramolecular Cyclization of 1,2-Aryldiamines
Faggyas, Réka J.,Sloan, Nikki L.,Buijs, Ned,Sutherland, Andrew
supporting information, p. 5344 - 5353 (2019/05/21)
An operationally simple method has been developed for the preparation of N-unsubstituted benzotriazoles by diazotization and intramolecular cyclization of a wide range of 1,2-aryldiamines under mild conditions, using a polymer-supported nitrite reagent and p-tosic acid. The functional group tolerance of this approach was further demonstrated with effective activation and cyclization of N-alkyl, -aryl, and -acyl ortho-aminoanilines leading to the synthesis of N1-substituted benzotriazoles. The synthetic utility of this one-pot heterocyclization process was exemplified with the preparation of a number of biologically and medicinally important benzotriazole scaffolds, including an α-amino acid analogue.
Short-circuiting azobenzene photoisomerization with electron-donating substituents and reactivating the photochemistry with chemical modification
Bandara, H. M. Dhammika,Cawley, Shannon,Gascon, Jose A.,Burdette, Shawn C.
supporting information; scheme or table, p. 2916 - 2919 (2011/06/28)
Azobenzene (AB undergoes (E → (Z isomerization upon exposure to light. Whereas the light-induced structural change can be exploited for numerous applications, a second, light-orthogonal switch would facilitate the development of new uses for AB derivative
ZN -CHELATING MOTIF-TETHERED SHORT -CHAIN FATTY ACIDS AS A NOVEL CLASS OF HISTONE DEACETYLASE INHIBITORS
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Page/Page column 28, (2008/06/13)
Zn -chelating motif-tethered fatty acids as histone deacetylase (HDAC) inhibitors. Compounds performed well in in vitro and in vivo tests.