227079-11-0Relevant articles and documents
1,5-Anhydro-2-deoxy-D-altritol oligonucleotides as conformationally restricted analogues of RNA
Allart, Brigitte,Van Aerschot, Arthur,Herdewijn, Piet
, p. 1523 - 1526 (2007/10/03)
As part of a project concerning the investigation of new hexitol nucleic acids (HNA), the 1,5-anhydro-2-deoxy-D-altritol nucleoside building blocks with a uracil, cytosine, adenine and guanine base moiety were synthesized. The uracil analogue was used for the automated synthesis of corresponding oligonucleotides. Hybridization capabilities of these altritol nucleic acids (ANA) are illustrated by the Tm values obtained for the (d(h)U)13/(dA)13 duplex.