227084-43-7Relevant articles and documents
Efficient activity of magnesium-aluminium hydrotalcite in the synthesis of amides
Morales-Serna, Jose Antonio,Jaime-Vasconcelos, Miguel Angel,Garcia-Rios, Erendira,Cruz, Alejandro,Angeles-Beltran, Deyanira,Lomas-Romero, Leticia,Negron-Silva, Guillermo Enrique,Cardenas, Jorge
, p. 23046 - 23050 (2013/11/19)
The synthesis of amides by coupling benzotriazole esters and amines can be achieved conveniently in moderate to excellent yields (50-95%) using a commercial, synthesized, calcined or reconstructed Mg-Al hydrotalcite instead of one of the classic bases (tertiary amines). The experimental results demonstrated that commercial and synthesized hydrotalcite can be quantitatively recovered from the reaction by simple filtration and reused for a number of cycles and that the reconstructed hydrotalcite is the most active form for the amide bond formation. Finally, to test the scope of the protocol for the synthesis of biologically relevant molecules, the total synthesis of Sansalvamide A was carried out.
Siamese depsipeptides: Constrained bicyclic architectures
Ruiz-Rodriguez, Javier,Spengler, Jan,Albericio, Fernando
supporting information; experimental part, p. 8564 - 8567 (2010/02/28)
The first members of a new class of depsipeptides with tartaric acid as the core unit, called Siamese depsipeptides, are described. These compounds were synthesized from a branched precursor in only one cyclization step. The structural manipulation of a n
