227094-09-9Relevant articles and documents
BRIDGED BICYCLIC KALLIKREIN INHIBITORS
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Page/Page column 262, (2016/12/26)
Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.
Novel bicyclic lactam inhibitors of thrombin: Potency and selectivity optimization through P1 residues
Levesque, Sophie,St-Denis, Yves,Bachand, Benoit,Preville, Patrice,Leblond, Lorraine,Winocour, Peter D,Edmunds, Jeremy J,Rubin,Siddiqui
, p. 3161 - 3164 (2007/10/03)
Peptidomimetic inhibitors of thrombin lacking the important Ser195-carbonyl interaction have been prepared. The binding energy lost after the removal of the activated carbonyl was recaptured through a series of modifications of the P1 residues of the bicyclic lactam inhibitors. Selected substituted compounds displayed useful pharmacological profiles both in vitro and in vivo.