227095-33-2

Upstream product

• 227095-32-1 (3R,5S,6S,4'S)-3-benzyl-5-<(tert-butyldimethylsilyl)oxy>-6-(2,2-dimethyldioxolan-4-yl)piperidin-2-one 
• 227095-31-0 4-O-tert-butyldimethylsilyl-5-(tert-butoxycarbonyl)amino-6,7-O-isopropylidene-2,3,5-trideoxy-D-ribo-heptonic acid 1,5-lactam 
• 140193-76-6 5-(N-benzylamino)-6,7-O-isopropylidene-2,3,5-trideoxy-D-ribo-hept-2-enonic acid 1,4-lactone 
• 197244-29-4 (S)-5-[(S)-Amino-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-dihydro-furan-2-one 

Relevant academic research and scientific papers

Diastereoselective synthesis of a novel lactam peptidomimetic exploiting vinylogous Mannich addition of 2-silyloxyfuran reagents

The total synthesis of a potential inhibitor of HIV-protease-the chiral nonracemic six-membered hydroxy lactam 6-has been accomplished, that involves, as key reaction, the highly diastereoselective vinylogous Mannich addition of furan-based silyloxy diene 7 to glyceraldeyde imine 8.