227097-01-0Relevant academic research and scientific papers
Synthetic studies toward pondaplin: Total synthesis of pondaplin analogues
Sabitha, Gowravaram,Swapna,Satheesh Babu,Yadav
, p. 6145 - 6148 (2005)
Syntheses of synthetic analogues of pondaplin 1 have been achieved. Final macrolide construction was accomplished using a Keck macrolactonization reaction.
A novel oxidative transformation of alcohols to nitriles: An efficient utility of azides as a nitrogen source
Rokade, Balaji V.,Malekar, Sanjeev K.,Prabhu, Kandikere Ramaiah
supporting information; scheme or table, p. 5506 - 5508 (2012/07/03)
An efficient methodology to oxidize benzylic and cinnamyl alcohols to their corresponding nitriles in excellent yields has been developed. This methodology employs DDQ as an oxidant and TMSN3 as a source of nitrogen in the presence of a catalytic amount of Cu(ClO4)2·6H 2O.
SUBSTITUTED HETEROARYL- AND ARYL- CYCLOPROPYLAMINE ACETAMIDES AND THEIR USE
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Page/Page column 75, (2011/04/26)
The invention relates to compounds of Formula (I): (A')x-(A)-(B)-(Z)-(L)-C(=O)NH2 or pharmaceutically acceptable salts or solvates thereof, wherein: (A) is heteroaryl or aryl; each (A'), if present, is indepedently chosen from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy, and cyano, wherein each (A') is substituted with 0, 1, 2 or 3 substituents independently chosen from halo, haloalkyl, aryl, arylalkoxy, alkyl, alkoxy, cyano, sulfonyl, sulfinyl, and carboxamide; X is 0, 1, 2, or 3; (B) is a cyclopropyl ring, wherein (A) and (Z) are covalently bonded to different carbon atoms of (B); (Z) is -NH-; and (L) is -(CH2)mCR1,R2-, wherein m is 0, 1, 2, 3, 4, 5, or 6, and wherein R1and R2 are each independently hydrogen or C1-C6 alkyl; provided that, if (L) is -CH2- or -CH(CH3)-, then X is not 0. The compounds of the invention are useful in the treatment of diseases such as cancer and neurodegenerative diseases.
