227181-18-2Relevant academic research and scientific papers
Hydrophobic and electronic factors in the design of dialkylglycine decarboxylase mimics
Chruma, Jason J.,Liu, Lei,Zhou, Wenjun,Breslow, Ronald
, p. 5873 - 5883 (2007/10/03)
The first functional catalytic mimic of the enzyme dialkylglycine decarboxylase is described. This system utilizes a hydrophobically modified polyethylenimine polymer, a pyridoxamine cofactor, and a 2-aryl-2-alkylglycine sacrificial amine source to convert α-keto acids to α-amino acids at biologically relevant temperatures with multiple turnovers of the pyridoxamine catalyst. The effects of hydrophobic and electronic factors in the 2,2-disubstituted sacrificial amine source and the pyridoxamine catalyst on turnover frequency and turnover number are explored.
Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel
Brown, Milton L.,Zha, Congxiang C.,Van Dyke, Christopher C.,Brown, George B.,Brouillette, Wayne J.
, p. 1537 - 1545 (2007/10/03)
Comparative molecular field analysis (CoMFA), a 3-D QSAR technique, is widely used to correlate biological activity with observed differences in steric and electrostatic fields. In this study, CoMFA was employed to generate a model, based upon 14 structur
