22719-81-9Relevant academic research and scientific papers
Synthesis, antifungal activity, and molecular docking studies of novel triazole derivatives
Wang, Nan,Chai, Xiaoyun,Chen, Ying,Zhang, Lei,Li, Wenjuan,Gao, Yijun,Bi, Yi,Yu, Shichong,Meng, Qingguo
, p. 384 - 388 (2013/07/28)
In order to meet the urgent need for novel antifungal agents with improved activity and broader spectrum, a series of 3/4-[[N-alkyl-2-(2,4-difluorophenyl)- 2-hydroxy-3-(1H-1, 2, 4-triazole)] propylamino] benzylethyl carbonate were designed, synthesized and evaluated as antifungal agents. The MIC80 values indicate that all the compounds showed only moderate or even no antifungal activities against nearly all the tested fungal pathogens. Moreover, the interactions of the most active compounds in the drug binding site of CACYP51 were also explored with the help of docking studies.
On the reactivity of imidazole carbamates and ureas and their use as esterification and amidation reagents
Heller, Stephen T.,Sarpong, Richmond
experimental part, p. 8851 - 8859 (2011/12/02)
The optimization, substrate scope, and mechanism of esterification and amidation of carboxylic acids mediated by imidazole-based reagents are discussed. The innate reactivity of carbonylimidazole reagents with a range of nucleophiles is also explored. New reagents developed for the synthesis of α,β-unsaturated esters are described, as are reagents for the preparation of tertiary amides directly from carboxylic acids.
