22725-38-8

Basic information

• Product Name: 3-Methoxy 5-Dibenzosuberenone
• Synonyms: 3-Methoxy 5-Dibenzosuberenone;3-Methoxy-5H-dibenzo[a,d]cyclohepten-5-one
• CAS NO: 22725-38-8
• Molecular Formula: C16H14O2
• Molecular Weight: 238.28116
• Product Categories: Aroamtics;Intermediates
• Mol File: 22725-38-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3-Methoxy 5-Dibenzosuberenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methoxy 5-Dibenzosuberenone(22725-38-8)
• EPA Substance Registry System: 3-Methoxy 5-Dibenzosuberenone(22725-38-8)

Safety Data

• Hazardous Substances Data: 22725-38-8(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

An intermediate in the preparation of pharmaceutically active Cyproheptadines.

Upstream product

• 2417-73-4 methyl 2-bromomethylbenzoate 
• 93012-06-7 4'-methylstilbene-2-carboxylic acid 
• 89-71-4 2-Methyl-benzoic acid methyl ester 
• 17910-76-8 3-Methoxy-dibenzo<1,4>cycloheptadien-5-on 

Downstream Products

• 30235-46-2 3-hydroxy-5H-dibenzo[a,d]cyclohepten-5-one 
• 64618-74-2 4-(3-methoxy-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-piperidine 

Relevant articles and documents

Synthesis and Anti-Influenza Virus Effects of Novel Substituted Polycyclic Pyridone Derivatives Modified from Baloxavir

In this work, a series of novel substituted polycyclic pyridone derivatives were designed and synthesized as potent anti-influenza agents. The cytopathic effect (CPE) assay and cytotoxicity assay indicated that all of the compounds possessed potent anti-influenza virus activity and relatively low cytotoxicity; some of them inhibited the replication of influenza A virus (IAV) at picomolar concentrations. Further studies revealed that, at a concentration of 3 nM, three compounds (10a, 10d, and 10g) could significantly reduce the M2 RNA amounts and M2 protein expression of IAV and inhibit the activity of RNA-dependent RNA polymerase (RdRp). Among them, (R)-12-(5H-dibenzo[a,d][7]annulen-5-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione (10a) was found to be a promising anti-influenza drug candidate with good human liver microsomal stability, as well as with better selectivity index and oral bioavailability than Baloxavir.

DIBENZOCYCLOHEPTENE COMPOUND

The present invention discloses a dibenzocycloheptene compound represented by the formula (I): ???wherein R1: hydrogen atom, halogen atom, etc., R2: hydrogen atom, halogen atom, etc., A: 5-membered or 6-membered heteroaromatic ring group containing 1 to 3 hetero atom(s) selected from the group consisting of nitrogen atom, oxygen atom and sulfur atom, and the heteroaromatic ring group, etc. may have halogen atom, nitrogen atom, etc. as substituent(s), B: formula; -CH=CH-, formula; -CH2O-, etc., Y: C1-C10 alkylene group which may have halogen atom, etc. as substituent(s), etc., Z: carboxyl group which may be protected, etc., m: an integer of 1 to 4, n: an integer of 1 to 3, ???------ represents a single bond or a double bond, or a pharmaceutically acceptable salt thereof and a medical composition containing the same as an effective ingredient which has leukotriene C4 antagonistic action and leukotriene E4 antagonistic action in addition to potent leukotriene D4 antagonistic action, and useful as antiasthmatic agent, antiallergic agent and anti-inflammatory agent.