22725-58-2

Basic information

• Product Name: Hydrazinecarbothioamide, 2-[[5-(4-nitrophenyl)-2-furanyl]methylene]-
• CAS NO: 22725-58-2
• Molecular Formula: C12H10N4O3S
• Molecular Weight: 290.302
• Mol File: 22725-58-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Hydrazinecarbothioamide, 2-[[5-(4-nitrophenyl)-2-furanyl]methylene]-(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazinecarbothioamide, 2-[[5-(4-nitrophenyl)-2-furanyl]methylene]-(22725-58-2)
• EPA Substance Registry System: Hydrazinecarbothioamide, 2-[[5-(4-nitrophenyl)-2-furanyl]methylene]-(22725-58-2)

Safety Data

• Hazardous Substances Data: 22725-58-2(Hazardous Substances Data)

Upstream product

• 7147-77-5 5-(4-nitrophenyl)-2-furaldehyde 
• 79-19-6 thiosemicarbazide 
• 98-01-1 furfural 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 58136-76-8 2-((5-(4-nitrophenyl)furan-2-yl)methylene)hydrazinecarboxamide 

Relevant articles and documents

A selective fluorogenic chemodosimeter for Hg2+ based on the dimerization of desulfurized product

A simple Hg2+-selective chemodosimetric system based on thiosemicarbazone was investigated. The transformation of thiosemicarbazone into semicarbazone selectively exerted by Hg2+ ions and the dimerization of semicarbazone resulted in a pronounced OFF-ON-type fluorescent signaling behavior. The coexistent metal ions, such as Fe3+, Ca2+, Cu2+, Co2+, Ni2+, Cd2+, Pb 2+, Zn2+, Cr3+, Mg2+, Na +, K+, and Fe2+, had no obvious interference with the detection of Hg2+. In addition, S12-Hg 2+ plays a high sensitivity for basic anions to form an 'OFF-ON-OFF' type signaling behavior, with the Hg2+-induced emission spectra can be quenched. Moreover, test strips based on S12 exhibited a good selectivity to Hg2+. We believe the test strips could act as a convenient and efficient Hg2+ test kit.

Synthesis of some new 2,4-disubstituted thiazoles as possible antibacterial and anti-inflammatory agents

A series of arylthioureas (1), aromatic aldehyde thiosemicarbazones (2) and 5-aryl-2-furfuraldehyde thiosemicarbazones (3) were condensed with 2,4-dichloro-5-fluorophenacyl bromide to yield respective arylaminothiazoles, arylidene/5-aryl-2-furfurylidene hydrazinothiazoles (4). The newly synthesized compounds were characterized by IR, 1H-NMR and mass spectral studies. These compounds were also screened for their antibacterial and anti-inflammatory activities. Two of the newly synthesized compounds showed anti-inflammatory activity comparable with that of Ibuprofen.