227286-91-1Relevant academic research and scientific papers
Enantiospecific synthesis of (+)-ribasine
Ollero, Lourdes,Castedo, Luis,Dominguez, Domingo
, p. 4445 - 4456 (1999)
The alkaloid (+)-ribasine was synthesized by stereocontrolled addition of substituted α-lithium-o-toluate 6d to enantiomerically pure (R)-N-(9- phenylfluoren-9-yl)-2-amino-5,6-(methylenedioxy)indan-1-one [(+)-5]. Aminoindanone (+)-5 was prepared from amino acid (-)-15 obtained by diastereoselective alkylation of a chiral glyeme enolate synthon.
